{"id":"W2165632524","doi":"10.1016/j.lfs.2011.06.010","title":"Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors","year":2011,"lang":"en","type":"article","venue":"Life Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Institut de Recherches Servier; Alberta Innovates - Technology Futures; Alberta Cancer Foundation","keywords":"CHEK1; G2-M DNA damage checkpoint; Topoisomerase; Kinase; Cancer cell; Protein kinase A; DNA-PKcs; DNA damage; In vitro; Biology; Cell cycle checkpoint; Chemistry; Cancer research; Biochemistry; Cell biology; Cell cycle; DNA; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640721,0.00009843903,0.0001187143,0.00008094854,0.00003873538,0.000009925785,0.00008404897,0.00006152384,0.000008454338],"category_scores_gemma":[0.000003981106,0.00007999442,0.00001652462,0.0002150325,0.0001589605,0.00001097062,0.00003234354,0.00004184974,9.527135e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001204057,"about_ca_system_score_gemma":0.00006410657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110056,"about_ca_topic_score_gemma":0.0004145089,"domain_scores_codex":[0.999284,0.00001826561,0.0001829001,0.0002585835,0.0001013787,0.0001549175],"domain_scores_gemma":[0.9997376,0.000002398113,0.00009924407,0.00008322221,0.00002352032,0.00005404163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007923317,0.0001077278,0.004389222,0.000008635565,0.000004605809,6.360696e-7,0.0002007062,0.000004364815,0.9946747,0.00001447657,0.000005302494,0.0005103615],"study_design_scores_gemma":[0.0006082901,0.0002406314,0.002684709,0.00002933793,0.000004653116,5.445612e-7,0.0001290665,0.00005813946,0.995939,0.000008409394,0.0001846912,0.0001125586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993402,0.0001992935,0.00006417532,0.00004365251,0.00007210759,0.0001371944,0.00003294307,0.000002978668,0.0001074178],"genre_scores_gemma":[0.9994622,0.000158043,0.0001357828,0.0001186927,0.00003365584,0.00002265686,0.00001947425,0.000006944602,0.00004247911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704513,"threshold_uncertainty_score":0.3262078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192260178608618,"score_gpt":0.2461790293912696,"score_spread":0.2269530115304078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}