{"id":"W2165632524","doi":"10.1016/j.lfs.2011.06.010","title":"Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors","year":2011,"lang":"en","type":"article","venue":"Life Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Institut de Recherches Servier; Alberta Innovates - Technology Futures; Alberta Cancer Foundation","keywords":"CHEK1; G2-M DNA damage checkpoint; Topoisomerase; Kinase; Cancer cell; Protein kinase A; DNA-PKcs; DNA damage; In vitro; Biology; Cell cycle checkpoint; Chemistry; Cancer research; Biochemistry; Cell biology; Cell cycle; DNA; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002924067,0.0006344627,0.0005343268,0.0005088812,0.0002383269,0.0004547845,0.0003313854,0.0002581777,0.001975928],"category_scores_gemma":[0.0003823845,0.0002969042,0.0004127111,0.0004294244,0.0001716411,0.0002679673,0.0001115207,0.0006034122,0.0003456519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005105882,"about_ca_system_score_gemma":0.0003541349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002513595,"about_ca_topic_score_gemma":0.003773008,"domain_scores_codex":[0.9997783,0.00005441446,0.00002517471,0.00003434873,0.00005299815,0.00005469896],"domain_scores_gemma":[0.9997787,0.00007762342,0.00003585731,0.00002363665,0.00005969289,0.00002453189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006110297,0.000200914,0.0004868094,0.0001170238,0.00003819744,0.00004411728,0.00002416948,0.0007644452,0.9937624,0.0001029268,0.0001514261,0.003696505],"study_design_scores_gemma":[0.00002779951,0.0004476433,0.001839862,0.000004601406,0.00004349863,0.00009336421,0.00001645578,0.0008048092,0.994979,0.0000150934,0.001725101,0.000002802111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765615,0.01158528,0.007012629,0.000150153,0.00007898764,0.0001471974,0.002074717,0.0001224009,0.002267012],"genre_scores_gemma":[0.9786204,0.005908816,0.005864192,0.00006391232,0.00003877417,0.0001364195,0.005518508,0.00005256502,0.00379649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002513595,"threshold_uncertainty_score":0.006610096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0192260178608618,"score_gpt":0.2461790293912696,"score_spread":0.2269530115304078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}