{"id":"W2165654130","doi":"10.1186/1478-811x-10-30","title":"Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages","year":2012,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Inflammation; Adipose tissue; Skeletal muscle; Endocrinology; Internal medicine; Cytokine; Insulin resistance; Adipose tissue macrophages; Myocyte; CCL2; GLUT4; Tumor necrosis factor alpha; Macrophage; Proinflammatory cytokine; Saturated fatty acid; Chemistry; Cell biology; Biology; Fatty acid; Medicine; White adipose tissue; Biochemistry; Insulin; Chemokine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006588274,0.0002052288,0.0002568558,0.0001175511,0.0003172365,0.00005880296,0.0001628394,0.0001036349,0.0001218415],"category_scores_gemma":[0.0000384542,0.0001652841,0.0000439189,0.0001142766,0.0001533263,0.0004765095,0.0000584706,0.0002204523,0.00001484787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006200642,"about_ca_system_score_gemma":0.0001043446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002547435,"about_ca_topic_score_gemma":0.000004873365,"domain_scores_codex":[0.998705,0.0003961124,0.0002526211,0.0001846351,0.0001930442,0.0002685634],"domain_scores_gemma":[0.998445,0.0002144045,0.0001802243,0.000708271,0.0001427799,0.0003093735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001679013,0.0004104351,0.01116459,0.0001782541,0.00007625753,0.000006119393,0.01107427,0.000114152,0.9700689,0.00027883,0.00003677035,0.004912435],"study_design_scores_gemma":[0.002576901,0.00017879,0.4096282,0.0001858355,0.0002272999,0.00001767343,0.006186161,0.0006821154,0.5540905,0.00003355188,0.02576307,0.0004299248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911919,0.007092532,0.0001699241,0.000184353,0.00004414979,0.0003576999,0.000006021899,0.0001513017,0.000802101],"genre_scores_gemma":[0.9963509,0.00107213,0.001833684,0.0002050106,0.00009057714,0.00003812372,0.00009886974,0.0000358404,0.0002749001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4159784,"threshold_uncertainty_score":0.6740091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02425182936818252,"score_gpt":0.2586725028522671,"score_spread":0.2344206734840846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}