{"id":"W2165655956","doi":"10.1038/sj.embor.7401161","title":"NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production","year":2008,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":313,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Istituto Pasteur-Fondazione Cenci Bolognetti; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"Cell biology; Reactive oxygen species; Biology; Mitochondrion; Kinase; Signal transduction; Mitochondrial ROS; Receptor; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002612532,0.0002260923,0.000318332,0.0001305828,0.0005124132,0.00002728038,0.00006669999,0.000302615,0.0002997699],"category_scores_gemma":[0.0002746732,0.0002052544,0.00008417112,0.0001192909,0.0002334816,0.0003889998,0.00007168771,0.0002945749,0.0001246368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006899064,"about_ca_system_score_gemma":0.0001007309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001284951,"about_ca_topic_score_gemma":0.000006473962,"domain_scores_codex":[0.9984782,0.000158471,0.0004448814,0.0005236546,0.00008439898,0.0003103635],"domain_scores_gemma":[0.9989614,0.00006521955,0.0004071372,0.0004283269,0.0001134027,0.00002450872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000268407,0.00004606472,0.001191567,0.00001077165,0.0001009399,0.00003912371,0.0050739,2.908166e-7,0.8719068,0.00001460078,0.1204403,0.0009072237],"study_design_scores_gemma":[0.0002480496,0.00009299017,0.005221067,0.00003549253,0.00002217603,0.001406492,0.0006403548,1.670671e-7,0.7381932,0.00007410352,0.2538699,0.0001960973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918929,0.002099406,0.00004261826,0.000561097,0.003353294,0.0004166637,0.00001206169,0.0001077766,0.001514203],"genre_scores_gemma":[0.9769802,0.0005425726,0.0001083414,0.0001136773,0.0002958258,0.00005166476,0.0004251231,0.00002635344,0.02145623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1337136,"threshold_uncertainty_score":0.837003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432550833270825,"score_gpt":0.209640868379053,"score_spread":0.1853153600463447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}