{"id":"W2165667087","doi":"10.1186/1743-422x-10-243","title":"Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30","year":2013,"lang":"en","type":"article","venue":"Virology Journal","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Centers for Disease Control and Prevention; University of Ottawa","keywords":"Biology; Virulence; Mutant; Virology; Influenza A virus; Gene; Virus; Influenza A virus subtype H5N1; Reverse genetics; Mutation; Mutagenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538407,0.0003855656,0.0002224049,0.0001516588,0.0001195046,0.0001871318,0.0001434094,0.000139481,0.001657801],"category_scores_gemma":[0.00005140216,0.0001141293,0.0002376978,0.0001018095,0.0002224263,0.00006941777,0.0001348046,0.0004558268,0.0004596857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006476232,"about_ca_system_score_gemma":0.0003034209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002907104,"about_ca_topic_score_gemma":0.004787413,"domain_scores_codex":[0.9998577,0.00001891125,0.00001443634,0.00002954463,0.00004531155,0.0000341768],"domain_scores_gemma":[0.9998914,0.00001402937,0.00003617289,0.00001235607,0.00001267353,0.00003343475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007646332,0.00003553556,0.0007344154,0.00002131368,0.000006833277,0.00002834006,0.000008154794,0.00003317304,0.9984555,0.00002079149,0.00005185187,0.0005277093],"study_design_scores_gemma":[0.00002803271,0.000579041,0.02524703,0.000009801837,0.00002557841,0.0004043306,0.00004329189,0.0005891558,0.9713108,0.00001634122,0.001741482,0.000005105185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975824,0.0002252267,0.0006315231,0.00004075161,0.00001303655,0.00001876677,0.0006313939,0.0000306954,0.0008260296],"genre_scores_gemma":[0.9950074,0.0002878029,0.001823783,0.00006648207,0.000006746081,0.00003755653,0.00102522,0.00001634891,0.001728717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002907104,"threshold_uncertainty_score":0.005780339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03233026638955375,"score_gpt":0.3260698490330535,"score_spread":0.2937395826434998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}