{"id":"W2165667087","doi":"10.1186/1743-422x-10-243","title":"Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30","year":2013,"lang":"en","type":"article","venue":"Virology Journal","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Centers for Disease Control and Prevention; University of Ottawa","keywords":"Biology; Virulence; Mutant; Virology; Influenza A virus; Gene; Virus; Influenza A virus subtype H5N1; Reverse genetics; Mutation; Mutagenesis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006224287,0.000309196,0.0005353199,0.000813371,0.0005979459,0.0001526121,0.0001143628,0.0002195799,0.00009861701],"category_scores_gemma":[0.000702183,0.0002612784,0.00003961289,0.000331668,0.000573174,0.0004756219,0.0002687649,0.0007579224,0.00005539229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781599,"about_ca_system_score_gemma":0.0001410009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005338999,"about_ca_topic_score_gemma":0.0001563885,"domain_scores_codex":[0.9976595,0.0002613364,0.0006024722,0.0004472884,0.0003484848,0.0006809061],"domain_scores_gemma":[0.9985938,0.000296437,0.0001622842,0.0002016429,0.0001708794,0.0005749593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006386203,0.0001001475,0.5422956,0.00008668915,0.0001739227,0.0003887082,0.002130281,0.0001383596,0.4486444,0.00007592315,0.0005181333,0.004809159],"study_design_scores_gemma":[0.006200435,0.001048185,0.9622664,0.0002004567,0.0001598125,0.002833474,0.0008986637,0.005941412,0.01733156,0.0008290744,0.001831721,0.000458749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951178,0.002076205,0.0008567014,0.00107773,0.00009483541,0.0006179493,0.00005426684,0.00003216389,0.00007232555],"genre_scores_gemma":[0.9922444,0.002701688,0.001067147,0.003623983,0.0001693944,0.00005874855,0.0000110929,0.00003904623,0.00008447568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4313129,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03233026638955375,"score_gpt":0.3260698490330535,"score_spread":0.2937395826434998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}