{"id":"W2165689508","doi":"10.1186/1476-4598-9-112","title":"Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Natural Compounds in Disease Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Chinese Academy of Sciences; National High-tech Research and Development Program; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Major Research Plan; Institute of Genetics; University of Texas MD Anderson Cancer Center","keywords":"Cancer research; Chronic myelogenous leukemia; Imatinib; Tyrosine kinase; ABL; breakpoint cluster region; Biology; Apoptosis; Philadelphia chromosome; Leukemia; Signal transduction; Chromosomal translocation; Immunology; Cell biology; Receptor; Gene; Genetics; Myeloid leukemia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001875905,0.0002687965,0.0003291675,0.0001675887,0.0001274035,0.00006178567,0.0001319445,0.0001303552,0.0001195011],"category_scores_gemma":[0.00008484122,0.0002600832,0.0000723921,0.0002869819,0.00006894498,0.0000757331,0.00009152308,0.0004734725,0.000005075093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009930113,"about_ca_system_score_gemma":0.0003300008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056719,"about_ca_topic_score_gemma":0.0001135744,"domain_scores_codex":[0.9983632,0.00005429805,0.0003536173,0.0004714894,0.0003419325,0.0004154449],"domain_scores_gemma":[0.9992161,0.00006429133,0.00016069,0.0003298461,0.00007299754,0.0001560094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007910735,0.0000441453,0.0009548131,0.0001519889,0.00009572239,0.0001509566,0.0002240305,0.0003886799,0.985727,0.000008591755,0.00006232577,0.01211261],"study_design_scores_gemma":[0.00148668,0.0001144607,0.001575094,0.0003713034,0.0001963696,0.00001165631,0.00005750869,0.001256631,0.9942659,0.0000426663,0.0003435889,0.0002781966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912785,0.007469408,0.0001459054,0.0002212495,0.000200285,0.0004271865,0.00001551512,0.00007027674,0.000171645],"genre_scores_gemma":[0.9940804,0.00008170107,0.005300401,0.0001585709,0.0001113648,0.0001407633,0.00003066356,0.00005725883,0.00003884867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01183441,"threshold_uncertainty_score":0.9999852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007575971949242262,"score_gpt":0.2645495505860327,"score_spread":0.2569735786367905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}