{"id":"W2165725371","doi":"10.1091/mbc.e10-01-0025","title":"Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species","year":2010,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"NADPH oxidase; Reactive oxygen species; Biology; Cell biology; Angiotensin II; Mitochondrial ROS; Transcription factor; Activator (genetics); Mitochondrion; Signal transduction; Hypoxia-inducible factors; Oxidative stress; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002649654,0.0004616268,0.000328187,0.0001522161,0.0001971414,0.0004502269,0.000259422,0.0004445497,0.0007314043],"category_scores_gemma":[0.0001055415,0.0001246101,0.000271972,0.0001345502,0.0003048689,0.0004790869,0.0002733417,0.0007992184,0.0002060899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003365704,"about_ca_system_score_gemma":0.0002091978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003175115,"about_ca_topic_score_gemma":0.0003098341,"domain_scores_codex":[0.9998274,0.00003707474,0.00001201804,0.000040763,0.00004052265,0.00004224384],"domain_scores_gemma":[0.9998994,0.0000118195,0.00003167212,0.00001147048,0.00001636591,0.00002927919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000191577,0.0000330677,0.0001739791,0.0002182308,0.000008702318,0.00009998169,0.00002110319,0.00004176909,0.9932643,0.0003872451,0.0001354713,0.005424597],"study_design_scores_gemma":[0.000032133,0.0004235248,0.008609507,0.00003105302,0.00004174474,0.0008881065,0.00005984457,0.001124177,0.9765331,0.0006161927,0.0116247,0.00001583595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8025199,0.150752,0.03690912,0.00279867,0.0007922045,0.0001216947,0.0006712815,0.0003508068,0.005084264],"genre_scores_gemma":[0.9654722,0.02556762,0.004655446,0.000385899,0.0002780688,0.00006860287,0.0005440586,0.00002800719,0.00300026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007314043,"threshold_uncertainty_score":0.00244683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005989942063336847,"score_gpt":0.2344622610992457,"score_spread":0.2284723190359088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}