{"id":"W2165770526","doi":"10.1124/dmd.115.065748","title":"Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange","year":2015,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Telmisartan; Chemistry; Organic anion transporter 1; Efflux; Transporter; Pharmacology; Chinese hamster ovary cell; Organic cation transport proteins; Non-competitive inhibition; Biochemistry; Receptor; Endocrinology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006092821,0.0006984956,0.001280388,0.0005560655,0.000363691,0.001400828,0.0008242634,0.0009349167,0.002062492],"category_scores_gemma":[0.0009412563,0.0003856073,0.0007612304,0.0004409817,0.0005721639,0.0009489924,0.0006459407,0.001199761,0.0007311159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000787935,"about_ca_system_score_gemma":0.0004016194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008861881,"about_ca_topic_score_gemma":0.0005457907,"domain_scores_codex":[0.9993105,0.0001481081,0.00006428386,0.0001369448,0.0002338201,0.0001063123],"domain_scores_gemma":[0.9992483,0.0001792624,0.0003352677,0.00006038638,0.000110245,0.00006650438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002347513,0.0002978125,0.02076985,0.0006169354,0.0005424844,0.002213595,0.000180832,0.001228905,0.8919896,0.009033922,0.003142205,0.06763629],"study_design_scores_gemma":[0.0004102655,0.00135467,0.07426891,0.0000960334,0.0005443834,0.01954242,0.0002055545,0.0117948,0.8497329,0.00421049,0.03771396,0.0001256146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944118,0.02117394,0.01974214,0.003168081,0.0002842066,0.00007953196,0.0008013147,0.000715133,0.009917727],"genre_scores_gemma":[0.9852037,0.004798249,0.002916922,0.0005029334,0.000086853,0.00003948596,0.0008017447,0.00008891181,0.005561028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062492,"threshold_uncertainty_score":0.006899774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009555942986027879,"score_gpt":0.2239252660218831,"score_spread":0.2143693230358553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}