{"id":"W2165798163","doi":"10.1371/journal.pone.0141251","title":"Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Heart, Lung, and Blood Institute; University of Washington","keywords":"Medicine; Critical illness; Endothelial activation; Intensive care medicine; Internal medicine; Bioinformatics; Endothelium; Biology; Critically ill","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128452,0.00007126875,0.0001419657,0.00003086832,0.00001386901,0.000004594268,0.00006460367,0.00009121106,0.00001005119],"category_scores_gemma":[0.0004479971,0.00006073116,0.00002816446,0.00008110417,0.00005955363,0.000003353328,0.00002406231,0.00003118797,0.000001560595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002721561,"about_ca_system_score_gemma":0.00004974904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003394177,"about_ca_topic_score_gemma":0.00004896393,"domain_scores_codex":[0.9994038,0.00003845082,0.0001359531,0.0001429569,0.0001589629,0.0001198684],"domain_scores_gemma":[0.9996148,0.00001927636,0.00006381283,0.0001085927,0.0001472725,0.00004622616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003369992,0.0007629187,0.3423881,0.00003157154,0.0001998132,0.000002285077,0.00004054442,0.000006817545,0.6558646,0.00003898775,0.0001604912,0.0001668936],"study_design_scores_gemma":[0.001061816,0.0002608704,0.05025368,0.000123712,0.0000464425,4.81091e-7,0.0002016587,0.00005456637,0.9476907,0.00002785152,0.0001277745,0.0001505061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990034,0.00009105697,0.0001259601,0.0002508534,0.00002128951,0.00008642352,0.00004337691,0.000005123356,0.0003725066],"genre_scores_gemma":[0.9993513,0.000008976647,0.0002657189,0.00011952,0.000061935,0.00001861646,0.00003976146,0.0000129082,0.0001212561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2921344,"threshold_uncertainty_score":0.2476545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06918404742863048,"score_gpt":0.2947541875900319,"score_spread":0.2255701401614014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}