{"id":"W2165823038","doi":"10.5339/qfarf.2012.bmp92","title":"Novel pyridinium-based cationic lipids as gene delivery vectors","year":2012,"lang":"en","type":"article","venue":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Gene delivery; Transfection; Cationic polymerization; Pyridinium; Chinese hamster ovary cell; Liposome; Chemistry; Viral vector; Cationic liposome; DNA; Rational design; Plasmid; Biochemistry; Biophysics; Combinatorial chemistry; Biology; Gene; Organic chemistry; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001244711,0.0002415022,0.0001828281,0.0002620807,0.0004315204,0.0001280542,0.0005156531,0.0002684687,0.001956455],"category_scores_gemma":[0.0004921695,0.000250029,0.0001318272,0.0003407011,0.0002576884,0.0001271915,0.000269834,0.0003118494,0.006073791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001290228,"about_ca_system_score_gemma":0.0004854626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007378514,"about_ca_topic_score_gemma":0.0002598867,"domain_scores_codex":[0.9972281,0.000195217,0.0003417588,0.0004923583,0.0006871489,0.001055347],"domain_scores_gemma":[0.9977776,0.00004991635,0.0001004539,0.0007059953,0.0009832953,0.0003826819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004624323,0.0006551803,0.01346138,0.00004400836,0.0001345877,0.000002049359,0.0003921681,0.0001518006,0.6730349,0.000412656,0.295208,0.01604087],"study_design_scores_gemma":[0.0005475716,0.0006651609,0.00621465,0.00001739883,0.00001426972,0.000012668,0.000605153,0.0003358105,0.1476727,0.00002958307,0.8435641,0.0003209877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869445,0.001513983,0.004426771,0.002116361,0.001178257,0.0005633734,0.0001866531,0.00005042841,0.003019694],"genre_scores_gemma":[0.9746264,0.000244358,0.000660772,0.0005923791,0.001510915,0.00009744338,0.00190824,0.00005263764,0.02030689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5483561,"threshold_uncertainty_score":0.9999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03831603529732377,"score_gpt":0.3516675941693391,"score_spread":0.3133515588720154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}