{"id":"W2165826635","doi":"10.1139/v07-025","title":"High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions","year":2007,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Nucleobase; RNA; Adduct; Morpholine; Alkylation; Michael reaction; Nucleophile; Stereochemistry; Piperidine; Guanosine; Deoxyribonucleoside; Cytidine; Protecting group; Nitromethane; DNA; Organic chemistry; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003016393,0.000772727,0.0003769166,0.0001818188,0.0001435926,0.0002807683,0.0002943742,0.0002680107,0.002100174],"category_scores_gemma":[0.0002151871,0.0003341961,0.0003007898,0.0001406407,0.0002000093,0.0002865474,0.0002158154,0.0006379161,0.001337678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073605,"about_ca_system_score_gemma":0.0003609448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001805248,"about_ca_topic_score_gemma":0.000758567,"domain_scores_codex":[0.9998141,0.00002490158,0.00002103517,0.00007076286,0.00003815252,0.00003116898],"domain_scores_gemma":[0.9998394,0.00002397491,0.0000557794,0.00002466745,0.00003144493,0.0000246105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001425807,0.000003266458,0.00001834803,0.00002508614,0.000001757317,0.00002053743,0.000006243071,0.00002844406,0.9990118,0.00004700966,0.0000193289,0.000803828],"study_design_scores_gemma":[0.000005108288,0.00008865842,0.0002465956,0.000003035264,0.000005793928,0.00009450502,0.000003731584,0.0002782758,0.9971502,0.00002196984,0.002097925,0.000004184643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7717441,0.002092969,0.2140691,0.0001843013,0.0001856345,0.000373709,0.00184663,0.001490182,0.008013434],"genre_scores_gemma":[0.8202423,0.001737979,0.1615371,0.000138481,0.00006175985,0.0002479895,0.003633641,0.0004126898,0.01198805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002100174,"threshold_uncertainty_score":0.007025778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296903104619725,"score_gpt":0.2351404387590619,"score_spread":0.2221714077128646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}