{"id":"W2165831983","doi":"10.1002/pola.20472","title":"Poly(ethyleneimine)/arginine–glycine–aspartic acid conjugates prepared with <i>N</i>‐succinimidyl 3‐(2‐pyridyldithio)propionate: An investigation of peptide coupling and conjugate stability","year":2004,"lang":"en","type":"article","venue":"Journal of Polymer Science Part A Polymer Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Chemistry; Aspartic acid; Peptide; Cysteine; Conjugate; Cystamine; Cationic polymerization; Glycine; Amino acid; Propionate; Serine; Polymer chemistry; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006707795,0.0003225504,0.0004278009,0.00009348671,0.0001815576,0.00008603861,0.0005349139,0.0001526817,0.0000407744],"category_scores_gemma":[0.00009687616,0.0002397748,0.0001065339,0.0003211158,0.001595088,0.0001317651,0.0001366983,0.0002393454,0.00000132803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004230652,"about_ca_system_score_gemma":0.00117533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007625035,"about_ca_topic_score_gemma":0.00002262134,"domain_scores_codex":[0.9975466,0.00003175908,0.0008095941,0.0005620851,0.0005870887,0.000462856],"domain_scores_gemma":[0.9976665,0.00002319464,0.0007668706,0.0005198084,0.0005553007,0.000468353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005511944,0.0000966274,0.01228512,0.00006094408,0.00006716268,0.000009894001,0.0005615174,0.00003906544,0.9860685,0.000007417859,0.0000263013,0.0002261948],"study_design_scores_gemma":[0.001423372,0.001181447,0.001024433,0.0001846147,0.00008457556,0.0002629964,0.001033525,0.00009978321,0.9943438,0.00003448577,0.00001776207,0.0003092538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989116,0.009971023,0.0001174335,0.0004197455,0.0001513111,0.0001057605,0.00002772065,0.0000108879,0.00008011536],"genre_scores_gemma":[0.9989601,0.0001934803,0.0002490544,0.0001887842,0.0002602309,0.0000086489,0.00002020942,0.00002392939,0.00009558658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01126069,"threshold_uncertainty_score":0.9777733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296553409169054,"score_gpt":0.2389083723451471,"score_spread":0.2259428382534565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}