{"id":"W2165848665","doi":"10.1038/sj.onc.1209888","title":"mTOR, translation initiation and cancer","year":2006,"lang":"en","type":"review","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":599,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Biology; PI3K/AKT/mTOR pathway; Translation (biology); Cell cycle; Cell growth; P70-S6 Kinase 1; Cell biology; Signal transduction; Protein kinase B; Cancer; Mechanistic target of rapamycin; Translational regulation; Cancer research; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123062,0.0002554114,0.0004352231,0.00005250863,0.00004830359,0.00002321104,0.0001118094,0.0004194995,0.00003633067],"category_scores_gemma":[0.00001036115,0.0002407428,0.0001578899,0.00009198887,0.00003812591,0.000002647683,0.00002837744,0.0001053521,0.000007825215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005645897,"about_ca_system_score_gemma":0.0002704898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004718001,"about_ca_topic_score_gemma":0.00006777386,"domain_scores_codex":[0.998949,0.00006803301,0.0002932734,0.000401789,0.0001174315,0.0001705069],"domain_scores_gemma":[0.9994893,0.00001392946,0.0001913635,0.0002098731,0.000046939,0.00004856081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004797904,0.00001205713,0.000005962484,0.001295114,0.00007291204,0.000001600368,0.000004892906,0.000006213128,0.003540264,0.000003950563,0.001628364,0.9934239],"study_design_scores_gemma":[0.0001714359,0.00005577221,0.000001817527,0.0007924659,0.000305479,0.00001208453,5.611813e-7,0.000003619758,0.001798506,0.000009073361,0.9965788,0.0002704114],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001518224,0.9973671,0.0003054732,0.00001318061,0.0003212427,0.0002842216,0.0001904045,0.00001326136,0.001353238],"genre_scores_gemma":[0.0001369328,0.9963758,0.00040567,0.00005306449,0.001202278,0.0001477751,0.001166873,0.00005775287,0.0004538519],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949504,"threshold_uncertainty_score":0.9817205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06133366454979256,"score_gpt":0.366595682322666,"score_spread":0.3052620177728734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}