{"id":"W2165848665","doi":"10.1038/sj.onc.1209888","title":"mTOR, translation initiation and cancer","year":2006,"lang":"en","type":"review","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":599,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Biology; PI3K/AKT/mTOR pathway; Translation (biology); Cell cycle; Cell growth; P70-S6 Kinase 1; Cell biology; Signal transduction; Protein kinase B; Cancer; Mechanistic target of rapamycin; Translational regulation; Cancer research; Messenger RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004956857,0.001621271,0.001967923,0.002191416,0.0005163545,0.001526111,0.00145292,0.001986285,0.003848254],"category_scores_gemma":[0.0004378366,0.0005085512,0.0003760051,0.003562441,0.001026187,0.001668216,0.0006600291,0.002969507,0.004102623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001143227,"about_ca_system_score_gemma":0.001153963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384285,"about_ca_topic_score_gemma":0.003132161,"domain_scores_codex":[0.9998319,0.00002061444,0.00001764012,0.00003541412,0.00006970159,0.00002468847],"domain_scores_gemma":[0.9998554,0.00004999207,0.00001937921,0.000007149674,0.00004415059,0.00002391442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002211478,0.0001116008,0.0001397068,0.007115646,0.00006906369,0.00049537,0.00004432385,0.0006174871,0.005278369,0.00759647,0.1231147,0.8551962],"study_design_scores_gemma":[0.00003344531,0.00004677105,0.0003319895,0.0004973955,0.00004716118,0.0009738001,0.0000297035,0.0001010693,0.0008067061,0.002516624,0.9946038,0.00001137613],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006539261,0.9974647,0.000169976,0.0003148589,0.0006533916,0.000003626867,0.00001436632,0.00001331383,0.0013003],"genre_scores_gemma":[0.001010278,0.995418,0.00026558,0.0003142404,0.0008212138,0.00001356296,0.0000479465,0.000003143723,0.002106131],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003848254,"threshold_uncertainty_score":0.01287371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06133366454979256,"score_gpt":0.366595682322666,"score_spread":0.3052620177728734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}