{"id":"W2165909199","doi":"10.1002/rcm.3329","title":"Determining protein adducts of fipexide: mass spectrometry based assay for confirming the involvement of its reactive metabolite in covalent binding","year":2007,"lang":"en","type":"article","venue":"Rapid Communications in Mass Spectrometry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; F. Hoffmann-La Roche","keywords":"Chemistry; Metabolite; Adduct; Cysteine; Glutathione; Microsome; Mass spectrometry; Biochemistry; Amino acid; Drug metabolism; Chromatography; Metabolism; Enzyme; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006961295,0.001065309,0.0004461376,0.001051789,0.000421552,0.000324546,0.0004589197,0.00114118,0.001244924],"category_scores_gemma":[0.0006582958,0.0003961817,0.0004133159,0.0007118088,0.0004371383,0.000425227,0.0004095948,0.0008204913,0.0006738112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003065524,"about_ca_system_score_gemma":0.0003762059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006517156,"about_ca_topic_score_gemma":0.001366486,"domain_scores_codex":[0.9993777,0.0001561873,0.00004221711,0.0001432118,0.0002082987,0.00007257921],"domain_scores_gemma":[0.999473,0.0001301727,0.0001302328,0.00006705115,0.0001311207,0.00006834115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006103719,0.00003026174,0.0005992251,0.00004536202,0.00001848632,0.00004901983,0.00002629078,0.00003455155,0.9981431,0.00003902958,0.00001453396,0.0009391331],"study_design_scores_gemma":[0.000005149901,0.0004034189,0.005002227,0.000005653352,0.00002989434,0.0002254419,0.00002685931,0.0006297283,0.992831,0.00004700601,0.0007863115,0.000007218119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8938432,0.007485096,0.09338674,0.0001641795,0.0001130042,0.0003510427,0.0009587145,0.0004238222,0.003274081],"genre_scores_gemma":[0.898187,0.00582744,0.08770118,0.0002826717,0.00006528463,0.0004378016,0.001591011,0.00006707455,0.005840493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244924,"threshold_uncertainty_score":0.004164696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1514846472384997,"score_gpt":0.4371948207227738,"score_spread":0.2857101734842741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}