{"id":"W2165943160","doi":"10.1088/1478-3975/2/4/s01","title":"Solvation and desolvation effects in protein folding: native flexibility, kinetic cooperativity and enthalpic barriers under isostability conditions","year":2005,"lang":"en","type":"article","venue":"Physical Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canada Research Chairs","keywords":"Barnase; Cooperativity; Chemistry; Solvation; Protein folding; Folding (DSP implementation); Chemical physics; Thermodynamics; Kinetic energy; Molecule; Statistical physics; Physics; Classical mechanics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000350876,0.0003640408,0.0003044211,0.0002483359,0.0003726132,0.0004016058,0.000428701,0.0003125232,0.0003504401],"category_scores_gemma":[0.0008725809,0.0001891883,0.0002736335,0.000166256,0.001167583,0.0008600144,0.0007171981,0.0003562747,0.00007034625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934533,"about_ca_system_score_gemma":0.0002176473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009763751,"about_ca_topic_score_gemma":0.0007782332,"domain_scores_codex":[0.9998912,0.00002543896,0.000004544408,0.00002545238,0.00002731304,0.00002612235],"domain_scores_gemma":[0.9997627,0.0001023796,0.00005352359,0.00002620942,0.00001826062,0.00003698073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007356709,0.0002507707,0.01388567,0.0002092011,0.0001028914,0.0008254408,0.000582775,0.3640525,0.5576753,0.04631205,0.0002063718,0.01516132],"study_design_scores_gemma":[0.00006002441,0.0003120801,0.01376195,0.000008903032,0.00004059507,0.0002976542,0.0001299806,0.8668538,0.08432235,0.03365833,0.0004977132,0.00005652243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901518,0.0003816157,0.008611387,0.00008260916,0.000004347611,0.000004888127,0.000008948803,0.00002761264,0.0007267784],"genre_scores_gemma":[0.9992804,0.00009673207,0.0004825217,0.000004978635,0.000002819173,0.000007506804,0.000006603589,0.000005960454,0.0001124818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009763751,"threshold_uncertainty_score":0.003580272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007586815294248169,"score_gpt":0.2829542255278746,"score_spread":0.2753674102336264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}