{"id":"W2165943560","doi":"10.1111/j.1399-3011.2004.00190.x","title":"Cyclic enkephalin analogs containing various <i>para</i>‐substituted phenylalanine derivatives in place of Tyr<sup>1</sup> are potent opioid agonists*","year":2005,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Agonist; Enkephalin; Stereochemistry; Phenylalanine; Receptor; μ-opioid receptor; Opioid; Opioid peptide; Vas deferens; Structure–activity relationship; Lipophilicity; Peptide; Biological activity; Amino acid; In vitro; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001568594,0.0002487191,0.0007139079,0.0007035081,0.0001959509,0.0000862785,0.0009131043,0.00011197,0.0001125061],"category_scores_gemma":[0.002134318,0.0002071401,0.0001969285,0.0009910691,0.0005094265,0.0004466796,0.0002879653,0.001482211,0.00005038659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001952658,"about_ca_system_score_gemma":0.0003190043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000137745,"about_ca_topic_score_gemma":0.0000610547,"domain_scores_codex":[0.9955896,0.0009730539,0.001078172,0.000444319,0.001109971,0.0008049207],"domain_scores_gemma":[0.9971191,0.001257122,0.0006113007,0.0003097731,0.0004350089,0.0002677505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009917141,0.0004589309,0.003000254,0.00005479333,0.00002287118,0.0008013285,0.001313463,0.01179137,0.9784381,0.0007093559,0.0006844607,0.001733301],"study_design_scores_gemma":[0.008871502,0.005839195,0.1010788,0.001560006,0.00004719315,0.001506218,0.005369896,0.009316627,0.8322625,0.001954058,0.0312087,0.0009853389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976688,0.0004660306,0.00004068264,0.0007407852,0.00005027008,0.0002312164,0.00001724724,0.00001469898,0.0007702525],"genre_scores_gemma":[0.9973,0.001170386,0.0005779506,0.000290359,0.0004059103,0.000006121999,0.000001633617,0.00003627588,0.0002113571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1461757,"threshold_uncertainty_score":0.8446928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09499979795457097,"score_gpt":0.3632468821114229,"score_spread":0.2682470841568519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}