{"id":"W2165943560","doi":"10.1111/j.1399-3011.2004.00190.x","title":"Cyclic enkephalin analogs containing various <i>para</i>‐substituted phenylalanine derivatives in place of Tyr<sup>1</sup> are potent opioid agonists*","year":2005,"lang":"en","type":"article","venue":"Journal of Peptide Research","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; Agonist; Enkephalin; Stereochemistry; Phenylalanine; Receptor; μ-opioid receptor; Opioid; Opioid peptide; Vas deferens; Structure–activity relationship; Lipophilicity; Peptide; Biological activity; Amino acid; In vitro; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008074681,0.0003648277,0.0002624622,0.00007777018,0.00009415837,0.0001950094,0.0002028929,0.0002480907,0.0009738267],"category_scores_gemma":[0.0001467095,0.0001249461,0.0001788058,0.0001075459,0.0001781386,0.000170397,0.000105242,0.0004073473,0.0003026189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001653626,"about_ca_system_score_gemma":0.0001173921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003108016,"about_ca_topic_score_gemma":0.0009507898,"domain_scores_codex":[0.9998792,0.00002394822,0.00001486579,0.00002105133,0.00002926456,0.00003150006],"domain_scores_gemma":[0.9998927,0.00002355889,0.00003471251,0.000008665384,0.000008814814,0.00003157658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002318731,0.00002944115,0.00007518419,0.00004626922,0.000007579522,0.0000623363,0.000006690869,0.00009665696,0.9981532,0.00002793201,0.00002332923,0.001239481],"study_design_scores_gemma":[0.00003496031,0.001578382,0.001794456,0.000006535667,0.00002211519,0.0003967859,0.00001538552,0.0002880048,0.9942774,0.00001515903,0.001561674,0.000009127468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959418,0.001816035,0.0005500025,0.00003140892,0.00002173137,0.00002222613,0.0001756585,0.0000195242,0.001421674],"genre_scores_gemma":[0.9959644,0.001198966,0.001592961,0.0000626044,0.00001401192,0.000020097,0.0003552644,0.000009077144,0.0007826432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009738267,"threshold_uncertainty_score":0.003257751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09499979795457097,"score_gpt":0.3632468821114229,"score_spread":0.2682470841568519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}