{"id":"W2165967649","doi":"10.1128/mcb.21.24.8346-8356.2001","title":"Mpe1, a Zinc Knuckle Protein, Is an Essential Component of Yeast Cleavage and Polyadenylation Factor Required for the Cleavage and Polyadenylation of mRNA","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation pour la Recherche Médicale; Canadian Food Inspection Agency; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Polyadenylation; Cleavage and polyadenylation specificity factor; Biology; Cleavage factor; Cleavage stimulation factor; Protein subunit; Messenger RNA; Saccharomyces cerevisiae; Cleavage (geology); Molecular biology; Post-transcriptional modification; RNA-binding protein; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006745484,0.0007238556,0.0002656,0.0002734139,0.0002539985,0.0002788489,0.0003050693,0.0003656221,0.001163388],"category_scores_gemma":[0.0001149361,0.0001949352,0.0002263163,0.0001670457,0.0002254533,0.0002192147,0.000349989,0.0005874612,0.001026099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003982061,"about_ca_system_score_gemma":0.0002038899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006307386,"about_ca_topic_score_gemma":0.001054454,"domain_scores_codex":[0.9999166,0.000004727242,0.000004886594,0.00002926464,0.00003323667,0.00001129265],"domain_scores_gemma":[0.9999211,0.00001279891,0.00002178369,0.000008844941,0.000007923347,0.00002753354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004479454,0.00001020282,0.0003157735,0.00003987732,0.00000322389,0.00007482497,0.000008205372,0.00005939719,0.9974537,0.0000689998,0.00006295482,0.001857999],"study_design_scores_gemma":[0.00001159195,0.00006432187,0.0109277,0.000007460909,0.00001336255,0.0009606208,0.00001780611,0.0009565902,0.978137,0.00007587263,0.008819441,0.000008377716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827986,0.003635228,0.009893573,0.0001772435,0.0000339476,0.00004821868,0.001985111,0.0004425274,0.000985369],"genre_scores_gemma":[0.9685261,0.001530945,0.01200656,0.00007133145,0.00001580041,0.00005329878,0.008448033,0.0001109732,0.009236963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163388,"threshold_uncertainty_score":0.003891945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467078071284995,"score_gpt":0.2663437503420444,"score_spread":0.2516729696291945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}