{"id":"W2165967649","doi":"10.1128/mcb.21.24.8346-8356.2001","title":"Mpe1, a Zinc Knuckle Protein, Is an Essential Component of Yeast Cleavage and Polyadenylation Factor Required for the Cleavage and Polyadenylation of mRNA","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation pour la Recherche Médicale; Canadian Food Inspection Agency; Centre National de la Recherche Scientifique; Association pour la Recherche sur le Cancer","keywords":"Polyadenylation; Cleavage and polyadenylation specificity factor; Biology; Cleavage factor; Cleavage stimulation factor; Protein subunit; Messenger RNA; Saccharomyces cerevisiae; Cleavage (geology); Molecular biology; Post-transcriptional modification; RNA-binding protein; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052824,0.0001471878,0.0002044686,0.00005828736,0.000114009,0.00002057351,0.0001073866,0.0001844732,0.000006252386],"category_scores_gemma":[0.00004059728,0.0001175163,0.00006300848,0.00006053881,0.000274805,0.000009546787,0.0001085851,0.00007052779,2.580561e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005200137,"about_ca_system_score_gemma":0.00002733112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001871976,"about_ca_topic_score_gemma":0.00002717581,"domain_scores_codex":[0.9989622,0.000121733,0.0002514351,0.0003356625,0.00009557843,0.0002334241],"domain_scores_gemma":[0.999447,0.00001689505,0.0001288945,0.0002498692,0.00006693502,0.00009042018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000332351,0.00004434247,0.002077666,0.0000469974,0.00006712844,0.00000257516,0.0001127041,0.000001657881,0.9918644,0.000323329,0.00001671503,0.005110075],"study_design_scores_gemma":[0.0008907927,0.0008337757,0.004258446,0.00001437719,0.00003077614,0.0000160677,0.0001240348,0.001001135,0.9918387,0.0001555986,0.0007047842,0.0001314908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975332,0.003338302,0.02043949,0.0002120812,0.0000270364,0.0005444761,0.00006284034,0.000004862578,0.00003893166],"genre_scores_gemma":[0.998951,0.0003039995,0.0003254514,0.00005646254,0.00006367081,0.00002088508,0.0001391078,0.00001818773,0.0001212946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02361896,"threshold_uncertainty_score":0.4792176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467078071284995,"score_gpt":0.2663437503420444,"score_spread":0.2516729696291945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}