{"id":"W2165983791","doi":"10.1093/hmg/ddu735","title":"Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenne muscular dystrophy","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre","keywords":"TLR4; Biology; Duchenne muscular dystrophy; Inflammation; HMGB1; Innate immune system; Muscular dystrophy; Immunology; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004217126,0.0002907705,0.0002878277,0.0001532513,0.00009864813,0.00002535042,0.000358109,0.0003429315,0.00006524158],"category_scores_gemma":[0.00007987325,0.0003260848,0.000125467,0.0002137942,0.0001330714,0.000006325939,0.0001448491,0.0002740491,0.00003064146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003044397,"about_ca_system_score_gemma":0.00005389185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001156325,"about_ca_topic_score_gemma":0.0001188728,"domain_scores_codex":[0.9978787,0.0005561596,0.0004231051,0.0005368524,0.0001588843,0.0004462924],"domain_scores_gemma":[0.9990249,0.0000159668,0.000130243,0.0006690936,0.00007196933,0.00008781354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028898,0.0001621012,0.003484005,0.00002825414,0.00004162921,0.000006043028,0.000151584,0.002381926,0.9923057,0.0006487892,0.00008806147,0.0005990035],"study_design_scores_gemma":[0.008160179,0.00280132,0.4044888,0.0001521942,0.0001037366,0.00002285901,0.0004047718,0.001683312,0.5018066,0.04321646,0.03481781,0.002341942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948853,0.001926224,0.001581346,0.00008513049,0.0001134618,0.0003628977,0.000005882169,0.00001544183,0.001024262],"genre_scores_gemma":[0.9970952,0.0002029244,0.001033114,0.001056258,0.00007087512,0.00005488123,0.0003425009,0.00005010639,0.00009418018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4904991,"threshold_uncertainty_score":0.9999191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007679096850552586,"score_gpt":0.2494286712429439,"score_spread":0.2417495743923913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}