{"id":"W2165997291","doi":"10.1124/jpet.302.3.1046","title":"Proteinase-Activated Receptor 2: Differential Activation of the Receptor by Tethered Ligand and Soluble Peptide Analogs","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"","keywords":"Trypsin; Receptor; Ligand (biochemistry); Chemistry; Peptide; Stereochemistry; Agonist; Mutagenesis; Biochemistry; Mutation; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114476,0.000271844,0.0002852007,0.0001199613,0.0001376374,0.0004235497,0.0003479756,0.0004410553,0.001928635],"category_scores_gemma":[0.000395093,0.0001888353,0.0002288381,0.00014023,0.0002357666,0.0004714738,0.0001984521,0.0005731985,0.0004561683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469475,"about_ca_system_score_gemma":0.0001764722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002378152,"about_ca_topic_score_gemma":0.0004437473,"domain_scores_codex":[0.9997916,0.00005584965,0.00001312632,0.00002512371,0.00004365449,0.00007078746],"domain_scores_gemma":[0.9998981,0.00004309408,0.00001173367,0.00001315532,0.00000770662,0.00002620609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007167066,0.0000447353,0.00008941392,0.00004140567,0.000006618598,0.0001214386,0.00002491932,0.0002552355,0.9964101,0.0003802358,0.00006340359,0.001845771],"study_design_scores_gemma":[0.000119278,0.0009887429,0.002317081,0.000006562404,0.00002772736,0.001237141,0.0000407163,0.002686392,0.9905171,0.0001817126,0.001862265,0.00001537062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956633,0.001286523,0.001471702,0.0001131974,0.00003363949,0.00001892133,0.00007071353,0.00002112861,0.001320868],"genre_scores_gemma":[0.9958386,0.0006675511,0.001408647,0.00009509445,0.00002857517,0.0000202072,0.0001625842,0.000009705649,0.001768968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928635,"threshold_uncertainty_score":0.006451905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03602578410636396,"score_gpt":0.309212051694009,"score_spread":0.273186267587645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}