{"id":"W2166000633","doi":"10.1073/pnas.1400680111","title":"Translocation domain mutations affecting cellular toxicity identify the <i>Clostridium difficile</i> toxin B pore","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Pore-forming toxin; Biology; Clostridium difficile toxin B; Chromosomal translocation; Cytosol; Cell biology; Transmembrane domain; Transmembrane protein; Toxin; Clostridium difficile; Internalization; Biochemistry; Clostridium difficile toxin A; Amino acid; Cell; Microbial toxins; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026809,0.000299652,0.0002049662,0.0001316698,0.0001298005,0.0001883921,0.0001806003,0.000263821,0.0008789662],"category_scores_gemma":[0.0001968617,0.00009935603,0.0002269953,0.0001101349,0.0003848068,0.0001410445,0.0002309557,0.000435374,0.0003097187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130432,"about_ca_system_score_gemma":0.0001977904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009850031,"about_ca_topic_score_gemma":0.001010958,"domain_scores_codex":[0.9998791,0.00002867188,0.00001636775,0.00002273193,0.00002922938,0.00002394677],"domain_scores_gemma":[0.9998631,0.00003719711,0.00004986394,0.00001108639,0.000008787343,0.00002987236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009598711,0.00003108048,0.0002495635,0.00002156848,0.000007193536,0.0001115359,0.00001344854,0.0001253496,0.9981216,0.00009680104,0.00002236641,0.001103621],"study_design_scores_gemma":[0.00002557807,0.000401705,0.004451223,0.00001041213,0.00002218177,0.0009218792,0.00003661347,0.0009268648,0.9920394,0.00005749,0.001099441,0.000007063137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956787,0.0003425497,0.002886017,0.00004908252,0.00001603085,0.00003981964,0.0001630096,0.00007708461,0.0007477726],"genre_scores_gemma":[0.9973484,0.0001747095,0.00189281,0.00003478676,0.000002946389,0.000008989,0.0001567138,0.00002159312,0.0003590212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009850031,"threshold_uncertainty_score":0.002940416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03827018611115472,"score_gpt":0.3258705947728566,"score_spread":0.2876004086617019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}