{"id":"W2166033642","doi":"10.1002/pro.590","title":"Discordant and chameleon sequences: Their distribution and implications for amyloidogenicity","year":2011,"lang":"en","type":"article","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Computational biology; Protein secondary structure; Evolutionary biology; Biology; Protein folding; Sequence (biology); Amyloid fibril; Protein structure; Protein structure prediction; Amyloid (mycology); Genetics; Biochemistry; Medicine; Amyloid β","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000226911,0.00008013657,0.00006157345,0.00001530939,0.0002341442,0.00003059215,0.0001592235,0.00003370797,7.384349e-7],"category_scores_gemma":[0.00009036306,0.00006094941,0.00001765548,0.00009499738,0.0005552,0.00001287494,0.0001142596,0.00003098424,1.52995e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008807079,"about_ca_system_score_gemma":0.00006730472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003038372,"about_ca_topic_score_gemma":0.00002803673,"domain_scores_codex":[0.999357,0.000009226036,0.00008638103,0.0003223408,0.00004702401,0.0001780576],"domain_scores_gemma":[0.999607,0.000003683223,0.00004879931,0.000194427,0.00007298918,0.00007313408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001864024,0.000007893995,0.001961786,0.000009715064,0.00000271774,6.692598e-8,0.00006151281,2.232081e-7,0.9780188,0.009408707,0.00000273277,0.01050719],"study_design_scores_gemma":[0.0001842664,0.0002598751,0.04224254,0.00001026032,0.00000590194,0.00003012418,0.00006201225,0.0002122549,0.9229546,0.03309588,0.0007698778,0.0001723893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9236585,0.0003408659,0.07511855,0.0001236482,0.00002054092,0.0005090824,0.0001138118,0.000007837346,0.0001071754],"genre_scores_gemma":[0.9935458,0.0000617057,0.006127288,0.00004154511,0.00002844023,0.0001443885,0.00002726101,0.000003834723,0.00001971952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06988733,"threshold_uncertainty_score":0.2485445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02113082519733472,"score_gpt":0.2570878448695451,"score_spread":0.2359570196722104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}