{"id":"W2166056954","doi":"10.1158/1078-0432.ccr-07-1187","title":"<i>N</i>-Acetylcysteine Protects Melanocytes against Oxidative Stress/Damage and Delays Onset of Ultraviolet-Induced Melanoma in Mice","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Center for Research Resources; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute","keywords":"Oxidative stress; Acetylcysteine; Glutathione; In vivo; Melanocyte; Melanoma; DNA damage; Pathogenesis; Cancer research; Pharmacology; Antioxidant; Chemistry; Medicine; Biology; Immunology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108553,0.0004366664,0.0003571815,0.0003680828,0.0001600605,0.0002292497,0.0003486963,0.0003892464,0.001365746],"category_scores_gemma":[0.0001493819,0.0001855004,0.0002983243,0.0001464162,0.0002862187,0.0002335468,0.0001089459,0.0006374387,0.0003376963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128153,"about_ca_system_score_gemma":0.0003783954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002948,"about_ca_topic_score_gemma":0.001641576,"domain_scores_codex":[0.9998456,0.00002846927,0.00002314301,0.00003505967,0.00003286466,0.00003483571],"domain_scores_gemma":[0.9997498,0.00002203375,0.0001039611,0.0000274595,0.00003430627,0.00006240315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008818283,0.0001522242,0.000276096,0.0000492737,0.0000109919,0.00002921487,0.000009205386,0.00004642236,0.9967784,0.00004923645,0.00006326043,0.001653868],"study_design_scores_gemma":[0.0000666364,0.002332686,0.00299154,0.00001208721,0.00002830699,0.0001570632,0.00001595348,0.0003551883,0.9929261,0.00002423834,0.001086198,0.000004065812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929875,0.002236867,0.001814994,0.0002233518,0.00008539017,0.0000726582,0.0004934737,0.0002551118,0.001830669],"genre_scores_gemma":[0.9913385,0.001361738,0.003111594,0.0001360645,0.00002647145,0.00008064867,0.0005970131,0.00004871752,0.003299221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365746,"threshold_uncertainty_score":0.004568875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0815463929412166,"score_gpt":0.4475391846143938,"score_spread":0.3659927916731772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}