{"id":"W2166061898","doi":"10.1128/mcb.25.1.233-240.2005","title":"Characterization of a U2AF-Independent Commitment Complex (E′) in the Mammalian Spliceosome Assembly Pathway","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"snRNP; Spliceosome; Polypyrimidine tract; Biology; RNA splicing; Small nuclear ribonucleoprotein; Ribonucleoprotein; Splicing factor; Small nuclear RNA; Genetics; Polypyrimidine tract-binding protein; Cell biology; SR protein; Molecular biology; RNA; Gene; Non-coding RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001761412,0.0002463331,0.0002048232,0.0002042335,0.0003101498,0.0005802197,0.0003300649,0.0002654534,0.0007824934],"category_scores_gemma":[0.0003008311,0.000191809,0.0001544402,0.0001527162,0.0001671732,0.0003370903,0.0003122521,0.0003097013,0.0004419542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215402,"about_ca_system_score_gemma":0.0002750349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310522,"about_ca_topic_score_gemma":0.001583362,"domain_scores_codex":[0.9998865,0.00001406324,0.00001630404,0.00002761879,0.00003310275,0.00002236318],"domain_scores_gemma":[0.9998174,0.0000276656,0.0000316573,0.00003143473,0.000033503,0.00005833378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001601275,0.0000340185,0.001205374,0.00003101422,0.000007026605,0.0000955759,0.00003208832,0.00008087715,0.9964707,0.0004637728,0.00003964748,0.001379794],"study_design_scores_gemma":[0.00002759878,0.0002038664,0.0324472,0.00001687978,0.00003106337,0.0008790785,0.0001034458,0.002411411,0.9569671,0.0002673333,0.006632179,0.0000128621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940352,0.0008195266,0.003761188,0.00006602915,0.00001168242,0.00002497313,0.0003148915,0.00002510052,0.0009411838],"genre_scores_gemma":[0.9902057,0.000405359,0.004735764,0.00005713451,0.000009824167,0.00002593913,0.002689682,0.00001684704,0.001853766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310522,"threshold_uncertainty_score":0.002617717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392308512617986,"score_gpt":0.2514614561031429,"score_spread":0.237538370976963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}