{"id":"W2166064709","doi":"10.1110/ps.9.1.83","title":"Deleterious effects of β‐branched residues in the S<sub>1</sub>specificity pocket of<i>Streptomyces griseus</i>proteinase B (SGPB): Crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB","year":2000,"lang":"en","type":"article","venue":"Protein Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Medical Council of Canada","funders":"National Institute of General Medical Sciences; National Institutes of Health; Medical Research Council; Alberta Heritage Foundation for Medical Research; Purdue University","keywords":"Streptomyces griseus; Serine; Side chain; Dihedral angle; Chemistry; Stereochemistry; Hydrogen bond; Residue (chemistry); Serine Proteinase Inhibitors; Crystallography; Active site; Crystal structure; Hydrolase; Enzyme; Molecule; Streptomyces; Biochemistry; Biology; Serine protease; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001245228,0.0002688957,0.0006155992,0.0003082456,0.0001691685,0.00004373063,0.0005350062,0.00008858638,0.00006494231],"category_scores_gemma":[0.0002707901,0.0001500462,0.0001115952,0.001997874,0.001907338,0.0002405219,0.0001067419,0.0003234839,7.987027e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004808492,"about_ca_system_score_gemma":0.0002354102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007626667,"about_ca_topic_score_gemma":0.000457668,"domain_scores_codex":[0.9969172,0.0003970592,0.0006450206,0.0005316619,0.001103594,0.0004055052],"domain_scores_gemma":[0.9985226,0.0001560172,0.0003678133,0.0006804645,0.0001688194,0.0001043087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004519329,0.0002254408,0.0100518,0.0003771775,0.00001847316,0.00004991925,0.002440204,0.00006240511,0.9845032,0.0002036476,0.00001976326,0.001596032],"study_design_scores_gemma":[0.001734682,0.0003476271,0.290403,0.001124821,0.00002805717,0.00005329895,0.0005823005,0.0001903795,0.7039058,0.001469818,0.000009590281,0.0001506455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970794,0.0002047713,0.00005833623,0.0004668406,0.000009049298,0.001669191,0.00003657014,0.00001666855,0.0004592056],"genre_scores_gemma":[0.998524,0.00002680599,0.001126754,0.000202107,0.00002628349,0.00006584316,0.000004728943,0.00001241124,0.00001108644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2805974,"threshold_uncertainty_score":0.7027666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006911033467404569,"score_gpt":0.2279517504729339,"score_spread":0.2210407170055293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}