{"id":"W2166064778","doi":"10.1093/hmg/ddq173","title":"A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Consejo Nacional de Ciencia y Tecnología; National Institutes of Health; Michael Smith Health Research BC","keywords":"Biology; Haplotype; Genetics; Single-nucleotide polymorphism; Allele; Cholesterol; ABCA1; Allele frequency; Gene; Genotype; Endocrinology; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002332755,0.0002391121,0.000233721,0.0004304941,0.0003729337,0.0003515262,0.0001612093,0.0002983283,0.00218427],"category_scores_gemma":[0.0006770709,0.0001246232,0.0002460472,0.0006140557,0.0002941691,0.00008261683,0.0001589587,0.0003385218,0.0001813742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009517292,"about_ca_system_score_gemma":0.0001066492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004125604,"about_ca_topic_score_gemma":0.00286842,"domain_scores_codex":[0.9998443,0.00004281681,0.00001493683,0.00005238606,0.0000243367,0.00002122583],"domain_scores_gemma":[0.9996475,0.0001049736,0.0001022825,0.00003770311,0.0000321749,0.00007536456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001326697,0.0001190095,0.9394802,0.00004467557,0.0003271835,0.001901029,0.0003995576,0.00009551524,0.04753045,0.0002162636,0.0003808459,0.008178497],"study_design_scores_gemma":[0.00002220834,0.0001089538,0.9958104,0.000005980196,0.00008861667,0.002612632,0.0001245351,0.0001791177,0.0006665738,0.00008081932,0.0002936086,0.000006653544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995118,0.0001135746,0.00008454897,0.00001950901,0.000003105668,0.000001686191,0.00005270734,0.000004601556,0.0002083441],"genre_scores_gemma":[0.9995859,0.00005167432,0.0001094602,0.00002478661,0.000008526975,0.000002549167,0.00007091998,0.000003802655,0.0001423352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004125604,"threshold_uncertainty_score":0.008203149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526657792382947,"score_gpt":0.2802991661444315,"score_spread":0.255032588220602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}