{"id":"W2166069871","doi":"10.1242/dmm.010124","title":"Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases","year":2012,"lang":"en","type":"review","venue":"Disease Models & Mechanisms","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":346,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Neurodegeneration; Apolipoprotein E; Disease; Cholesterol; Medicine; Neuroscience; Dementia; Blood–brain barrier; Alzheimer's disease; Homeostasis; Internal medicine; Bioinformatics; Biology; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641809,0.0005245781,0.0007532171,0.001288717,0.0005130969,0.001342068,0.000313231,0.0007640539,0.0009711473],"category_scores_gemma":[0.0002636505,0.0001464524,0.0002960706,0.0008761387,0.0006867295,0.0007678208,0.0007047904,0.0008237443,0.0003814995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008357506,"about_ca_system_score_gemma":0.0006002405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001819163,"about_ca_topic_score_gemma":0.002127441,"domain_scores_codex":[0.9998168,0.00003476056,0.00002549089,0.00003125399,0.00004803646,0.00004361166],"domain_scores_gemma":[0.9998769,0.00002460923,0.00003404502,0.000005759245,0.00003415103,0.00002447935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009519791,0.0002412016,0.0278622,0.005212213,0.0003717516,0.007842522,0.001288673,0.0007888681,0.1552478,0.01624579,0.009266054,0.774681],"study_design_scores_gemma":[0.0001318359,0.001434879,0.2843638,0.003917404,0.00124442,0.04868553,0.004725792,0.002050998,0.1111824,0.06247867,0.4794682,0.0003159116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0790104,0.9055367,0.001928301,0.00507972,0.0005195976,0.00001954949,0.000137682,0.00006810686,0.007700036],"genre_scores_gemma":[0.1972075,0.7955232,0.001538648,0.0008600552,0.001071701,0.00002737585,0.00009155541,0.00001547333,0.003664477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001819163,"threshold_uncertainty_score":0.006063819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05493602415307394,"score_gpt":0.3245604074282037,"score_spread":0.2696243832751298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}