{"id":"W2166113451","doi":"10.1093/toxsci/55.2.284","title":"Metabolism of 3-Methylindole by Porcine Liver Microsomes: Responsible Cytochrome P450 Enzymes","year":2000,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Analytical Chemistry and Chromatography","field":"Chemistry","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"CYP2A6; Microsome; Cytochrome P450; Enzyme; Biochemistry; Hydroxylation; Metabolism; Quinidine; Chemistry; CYP2E1; CYP3A4; CYP2B6; Cytochrome; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002483072,0.0003650511,0.00026973,0.0002237651,0.0001640144,0.0001940727,0.000116543,0.0002641144,0.0009189756],"category_scores_gemma":[0.0002036686,0.0001244436,0.0003415424,0.0002080495,0.0001285575,0.0001543967,0.0001207386,0.0002479401,0.0005265722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001801102,"about_ca_system_score_gemma":0.0001926284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127977,"about_ca_topic_score_gemma":0.001798797,"domain_scores_codex":[0.9998567,0.00004656993,0.0000103465,0.00002563327,0.0000322614,0.0000283378],"domain_scores_gemma":[0.9998769,0.0000346017,0.00003167223,0.00001800678,0.00002432668,0.00001447708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002466232,0.0000270102,0.000782553,0.00004628401,0.00001127621,0.00007007785,0.00001379494,0.00005926244,0.9970261,0.00002030079,0.00003727007,0.001659343],"study_design_scores_gemma":[0.00002168028,0.001117423,0.01394646,0.000006377632,0.00004766589,0.0004026473,0.00002433113,0.0006716436,0.9820018,0.00002665782,0.00172661,0.00000674233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813089,0.00507222,0.0103354,0.0001729628,0.00003995043,0.00007393107,0.0009475463,0.0001158348,0.001933267],"genre_scores_gemma":[0.9826651,0.002791526,0.007130896,0.00012312,0.00003537712,0.00007495266,0.003754797,0.00003676127,0.00338745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127977,"threshold_uncertainty_score":0.003074288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646157085706308,"score_gpt":0.2553033418096747,"score_spread":0.2388417709526117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}