{"id":"W2166139320","doi":"10.1161/circulationaha.107.733212","title":"Enzymatic Activity of Lysosomal Carboxypeptidase (Cathepsin) A Is Required for Proper Elastic Fiber Formation and Inactivation of Endothelin-1","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; SickKids Foundation; Centre Hospitalier Universitaire Sainte-Justine; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Cathepsin; Enzyme; Cathepsin A; Endothelin receptor; Carboxypeptidase; Cathepsin D; Biochemistry; Cell biology; Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173473,0.0003288008,0.0002088538,0.0001993906,0.0001472493,0.0003726869,0.0002095522,0.0003319321,0.001442184],"category_scores_gemma":[0.0002586413,0.0001653506,0.0002501887,0.0001127263,0.0002826376,0.0002021266,0.0002398871,0.0003904989,0.0004927262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497713,"about_ca_system_score_gemma":0.000190704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002547986,"about_ca_topic_score_gemma":0.0002887187,"domain_scores_codex":[0.9998235,0.00002447776,0.0000298332,0.00004385004,0.00004079396,0.00003767557],"domain_scores_gemma":[0.9995713,0.0000574117,0.0001559142,0.00004175822,0.00003026077,0.0001434361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008972591,0.0000139679,0.0003693719,0.00001928425,0.000004821831,0.00008781399,0.000005615051,0.00002368717,0.9989339,0.00008077916,0.0000250839,0.0003461158],"study_design_scores_gemma":[0.00004472233,0.0001454836,0.0187043,0.00001185159,0.0000301239,0.001492351,0.0000349643,0.001157625,0.9751093,0.0001152516,0.003146867,0.000007126438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953002,0.0009723455,0.002379729,0.00008907291,0.00002654028,0.00001179326,0.0004480971,0.00008359697,0.0006885719],"genre_scores_gemma":[0.9956886,0.0003707335,0.001789457,0.00002624925,0.00000952509,0.0000287604,0.0006412216,0.00002614786,0.001419328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442184,"threshold_uncertainty_score":0.004824638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04978792429526702,"score_gpt":0.2942998626914958,"score_spread":0.2445119383962288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}