{"id":"W2166147515","doi":"10.1042/bst0351574","title":"Enhancement of oligomeric stability by covalent linkage and its application to the human p53tet domain: thermodynamics and biological implications","year":2007,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Tetramer; Oligomer; Chemistry; Covalent bond; Tandem; Dissociation (chemistry); Entropy (arrow of time); Protein engineering; Disulfide bond; Conformational entropy; Molecule; Biochemistry; Thermodynamics; Materials science; Polymer chemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003016681,0.0003103917,0.0007498506,0.0000311084,0.0001984633,0.00001021938,0.0001463677,0.0005351875,0.00004154683],"category_scores_gemma":[0.00001329823,0.0002199277,0.0004659803,0.000460458,0.0002743056,0.00001443589,0.00003049986,0.0005440498,0.000003778489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003125194,"about_ca_system_score_gemma":0.00009777307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642782,"about_ca_topic_score_gemma":0.000002502884,"domain_scores_codex":[0.9983184,0.00005507574,0.000591669,0.0005756526,0.0001976557,0.0002615495],"domain_scores_gemma":[0.9989009,0.0001287547,0.000183127,0.0004707293,0.00009961916,0.0002167955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002924226,0.001174525,0.000007886557,0.008990963,0.001037068,4.346029e-7,0.0007053022,9.48326e-7,0.5149858,0.0003532862,0.0007834687,0.4719311],"study_design_scores_gemma":[0.0007852395,0.0003466975,0.0001019182,0.001429253,0.001969272,0.0000641451,0.0001858005,0.00005983124,0.01389723,0.00008252518,0.980483,0.0005950797],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007987509,0.8431531,0.1447238,0.0005760171,0.00003535369,0.002763002,0.0006457237,0.00004747194,0.00006802131],"genre_scores_gemma":[0.02289292,0.9747199,0.000920132,0.0001611945,0.00005406866,0.0007053887,0.0004908239,0.00003448128,0.000021022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9796996,"threshold_uncertainty_score":0.896839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04618200490101913,"score_gpt":0.3346412396186706,"score_spread":0.2884592347176514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}