{"id":"W2166216392","doi":"10.1128/jvi.02357-09","title":"Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada Research Chairs; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Euskal Herriko Unibertsitatea; Ministerio de Ciencia e Innovación; Canada Research Chairs","keywords":"Epitope; Gp41; Isothermal titration calorimetry; Biology; Complementarity determining region; Neutralization; Dissociation constant; Biophysics; V3 loop; Epitope mapping; Binding site; Peptide; Neutralizing antibody; Antibody; Biochemistry; Molecular biology; Virology; Peptide sequence; Receptor; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008478374,0.0001834797,0.0005187837,0.0001709072,0.0004214432,0.00001452714,0.0004874169,0.0002176234,0.00006225596],"category_scores_gemma":[0.0002142255,0.0001094869,0.0002738765,0.0001929616,0.0005848695,0.0001612756,0.0001654211,0.001086307,0.00000848635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004407671,"about_ca_system_score_gemma":0.00009468235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002212087,"about_ca_topic_score_gemma":0.0002546345,"domain_scores_codex":[0.9980219,0.0005724495,0.0007059623,0.0001767252,0.0001088722,0.0004141025],"domain_scores_gemma":[0.9978253,0.0003936281,0.001272613,0.0003129559,0.0001592024,0.00003626795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007302698,0.0000760123,0.4449225,0.000024282,0.000146138,0.000005281728,0.0007119431,0.00003364082,0.5533826,0.0001280826,0.00005696717,0.0004394721],"study_design_scores_gemma":[0.002149003,0.0005312843,0.664916,0.0001930803,0.0001713601,0.001088065,0.0005324306,0.00003219412,0.3292645,0.0001316097,0.0008778373,0.0001126502],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99764,0.0001806511,0.00007523968,0.0006592186,0.001034103,0.0002610061,0.00002533363,0.00000793687,0.0001165589],"genre_scores_gemma":[0.9995022,0.00006124877,0.0002446895,0.0000542651,0.00007635216,0.000001768155,0.00001244692,0.00001517572,0.00003179065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2241181,"threshold_uncertainty_score":0.4719523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209944024900448,"score_gpt":0.3154965487302926,"score_spread":0.2733971084812881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}