{"id":"W2166216392","doi":"10.1128/jvi.02357-09","title":"Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding","year":2010,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada Research Chairs; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Euskal Herriko Unibertsitatea; Ministerio de Ciencia e Innovación; Canada Research Chairs","keywords":"Epitope; Gp41; Isothermal titration calorimetry; Biology; Complementarity determining region; Neutralization; Dissociation constant; Biophysics; V3 loop; Epitope mapping; Binding site; Peptide; Neutralizing antibody; Antibody; Biochemistry; Molecular biology; Virology; Peptide sequence; Receptor; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371188,0.0003835579,0.0002854322,0.0001217081,0.00009032284,0.0002178784,0.0002965364,0.0003289811,0.000663909],"category_scores_gemma":[0.0001245419,0.000120878,0.0002649374,0.00009989449,0.000213623,0.0001494473,0.0001526284,0.0005564311,0.0001978904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330701,"about_ca_system_score_gemma":0.0002124984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001930811,"about_ca_topic_score_gemma":0.001654665,"domain_scores_codex":[0.9997877,0.00002826886,0.00001399195,0.00002737561,0.00005554025,0.00008710046],"domain_scores_gemma":[0.9999206,0.0000264857,0.00001539193,0.000009666005,0.000005727432,0.00002207794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006665108,0.00003947108,0.0001177104,0.00001331666,0.00000448123,0.0000289446,0.000008595814,0.00008439325,0.9989914,0.00004914364,0.00001401018,0.0005817484],"study_design_scores_gemma":[0.00001119599,0.000359547,0.002823265,0.000003652188,0.000009394569,0.0001578019,0.00001403619,0.001063237,0.9948279,0.00001651371,0.0007096941,0.000003846632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99853,0.0003081596,0.0005918472,0.00001840018,0.000008806243,0.000007673124,0.0001040816,0.00001715097,0.0004138913],"genre_scores_gemma":[0.9983373,0.000185186,0.0006769561,0.00003828077,0.000003835362,0.000008238763,0.0002336064,0.000006658986,0.0005099887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930811,"threshold_uncertainty_score":0.003839195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209944024900448,"score_gpt":0.3154965487302926,"score_spread":0.2733971084812881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}