{"id":"W2166224820","doi":"10.1210/en.2010-0102","title":"Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling","year":2010,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Northern British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Hyperinsulinemia; Internal medicine; Endocrinology; Insulin resistance; Leptin; Insulin; Pancreatic hormone; Hyperinsulinism; Medicine; Pancreas; Biology; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002080074,0.0006812094,0.0005460139,0.0007317599,0.0001725077,0.0005969415,0.0002638751,0.0005875231,0.002537662],"category_scores_gemma":[0.0002717014,0.0005411124,0.0003337185,0.0002376085,0.0005295365,0.000429824,0.0003222205,0.002087926,0.0005390404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003607295,"about_ca_system_score_gemma":0.0002121415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000266774,"about_ca_topic_score_gemma":0.0005274721,"domain_scores_codex":[0.9996905,0.00004583643,0.00003417271,0.0001145869,0.00006646379,0.00004840969],"domain_scores_gemma":[0.9996002,0.00003767868,0.0001695508,0.00003134314,0.00001777991,0.0001434776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006100787,0.00009610851,0.0006958944,0.00003347009,0.00001605009,0.000359418,0.00003755424,0.00004213137,0.9963567,0.0001553649,0.00007408721,0.001523163],"study_design_scores_gemma":[0.0004067979,0.003761047,0.1108848,0.00008902344,0.000160935,0.008723558,0.0002150581,0.001480969,0.8685108,0.0007477664,0.004962031,0.00005727757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947207,0.001046267,0.001580704,0.0001909913,0.00005736328,0.00003723506,0.0005120304,0.0002075197,0.001647244],"genre_scores_gemma":[0.9892057,0.001652574,0.00270474,0.0002649436,0.00004143166,0.0001125729,0.0008330108,0.0001276147,0.005057396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002537662,"threshold_uncertainty_score":0.00848937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878270534409708,"score_gpt":0.2557687119570561,"score_spread":0.236986006612959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}