{"id":"W2166264038","doi":"10.1093/nar/gkh160","title":"Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Biology; Primer (cosmetics); Virology; NS5B; Polymerase; Polymerase chain reaction; Substrate specificity; Molecular biology; DNA polymerase; Hepacivirus; Enzyme; Hepatitis C virus; Biochemistry; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002845982,0.0006240493,0.0005357754,0.0002518847,0.0001384241,0.000331308,0.0002913226,0.0002923983,0.0008098288],"category_scores_gemma":[0.0002337782,0.0002149978,0.0003019733,0.0002301892,0.0002020961,0.0001571168,0.0001714634,0.0005322719,0.000380049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005636074,"about_ca_system_score_gemma":0.000318526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212309,"about_ca_topic_score_gemma":0.00371046,"domain_scores_codex":[0.9996899,0.00004861516,0.00003160656,0.00006926036,0.00009722925,0.00006338854],"domain_scores_gemma":[0.999859,0.00003278828,0.00003472035,0.00001695569,0.00003177349,0.00002472675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007038097,0.00003851766,0.0002222989,0.00004814327,0.000008657185,0.00002493073,0.00000927941,0.0001026072,0.9970772,0.00006991476,0.00002782749,0.002300307],"study_design_scores_gemma":[0.00003776573,0.0006995998,0.002439701,0.000008342713,0.00004704739,0.0003381358,0.000006460215,0.0008000089,0.9926271,0.0000178936,0.002971437,0.000006434839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765232,0.008803673,0.009935834,0.0001215188,0.0000424622,0.0002303995,0.0004333049,0.0001709847,0.003738503],"genre_scores_gemma":[0.9802665,0.003876833,0.01128443,0.0001006432,0.00001860988,0.0001132204,0.00137382,0.00002891379,0.002937077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212309,"threshold_uncertainty_score":0.004089296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1613579674934749,"score_gpt":0.4082987367299948,"score_spread":0.2469407692365199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}