{"id":"W2166264038","doi":"10.1093/nar/gkh160","title":"Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate","year":2004,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Biology; Primer (cosmetics); Virology; NS5B; Polymerase; Polymerase chain reaction; Substrate specificity; Molecular biology; DNA polymerase; Hepacivirus; Enzyme; Hepatitis C virus; Biochemistry; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002260795,0.0002676947,0.0005503302,0.00083642,0.0003983029,0.0001260964,0.0004256401,0.0002706623,0.0007160243],"category_scores_gemma":[0.0003422548,0.0002350654,0.0001503467,0.001381423,0.0009487189,0.0004392842,0.0001606124,0.0009811018,0.0001440618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004380864,"about_ca_system_score_gemma":0.001234265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00183931,"about_ca_topic_score_gemma":0.0002304592,"domain_scores_codex":[0.9950105,0.0002611605,0.0005984167,0.0007390535,0.002176085,0.0012148],"domain_scores_gemma":[0.9966596,0.0002005603,0.0001030561,0.001056515,0.001301197,0.0006790637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006282825,0.002325621,0.03472751,0.0005218554,0.0002496303,0.0007117001,0.001228339,0.000119974,0.9396598,0.0006745339,0.001236309,0.01226195],"study_design_scores_gemma":[0.01104069,0.005381031,0.02209353,0.000772687,0.00006963388,0.00006882597,0.0010442,0.0005192246,0.9512752,0.0005630514,0.006562995,0.000608946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933583,0.0001836168,0.0003094409,0.0003987534,0.0001271725,0.001640565,0.000062336,0.00006704147,0.00385283],"genre_scores_gemma":[0.9948566,0.00007870763,0.00403176,0.00003159096,0.0003527818,0.00005792551,0.00004878416,0.0001315071,0.0004103579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01263398,"threshold_uncertainty_score":0.958569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1613579674934749,"score_gpt":0.4082987367299948,"score_spread":0.2469407692365199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}