{"id":"W2166273913","doi":"10.1152/physiolgenomics.00181.2004","title":"Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells","year":2004,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Biology; Regulator; Gene expression; Cell biology; Gene; Regulation of gene expression; Smooth muscle; Anatomy; Molecular biology; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009150901,0.0002123247,0.0003149836,0.00003724369,0.00007108601,0.00000514134,0.00027262,0.0003467107,0.00005488883],"category_scores_gemma":[0.00002508927,0.000181672,0.0001492431,0.0001076981,0.0001613476,0.000004786455,0.0001664185,0.0001718806,0.000007501242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003366126,"about_ca_system_score_gemma":0.00006893485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003336686,"about_ca_topic_score_gemma":0.000009954536,"domain_scores_codex":[0.998634,0.00008447874,0.0003150249,0.0005565562,0.00008632098,0.0003236491],"domain_scores_gemma":[0.9993535,0.00001296033,0.0001296842,0.0003656664,0.00005446047,0.00008367272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001515685,0.0003561232,0.00004035927,0.000009525365,0.000022647,0.000001341988,0.0000970511,0.002196308,0.9964995,0.0002426312,0.0002143611,0.0001686007],"study_design_scores_gemma":[0.001034045,0.0006196713,0.02144272,0.0000085306,0.00000937698,3.585971e-7,0.00007920422,0.0000295893,0.9671379,0.009171486,0.0002437594,0.0002233883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990571,0.0001441971,0.0002869695,0.00005045042,0.00005428203,0.0002155561,0.00003329009,0.00001281559,0.0001453408],"genre_scores_gemma":[0.9976925,0.0001053286,0.001560385,0.000383356,0.0001080651,0.00002512253,0.00009379875,0.00001931157,0.00001218519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02936161,"threshold_uncertainty_score":0.7408369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273107619693742,"score_gpt":0.2420086899635999,"score_spread":0.2292776137666625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}