{"id":"W2166275641","doi":"10.1093/toxsci/kfr061","title":"Bisphenol A Disrupts Steroidogenesis in Human H295R Cells","year":2011,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"King Saud University; National Natural Science Foundation of China; State Key Laboratory in Marine Pollution; Western Economic Diversification Canada; Chinese Academy of Sciences; City University of Hong Kong","keywords":"Androstenedione; Aromatase; Internal medicine; Endocrinology; Estrone; Chemistry; Testosterone (patch); Cell culture; Adrenocortical carcinoma; Leydig cell; Hydroxyprogesterone; Hormone; Biology; Steroid; Androgen; Luteinizing hormone; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005853929,0.0005354249,0.0005333585,0.0004962658,0.0005035066,0.0004844696,0.0004393503,0.0004569235,0.002946911],"category_scores_gemma":[0.0002490753,0.0003005728,0.0008790393,0.000751127,0.0003303372,0.0002018671,0.0003785037,0.0005936858,0.002280685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004902953,"about_ca_system_score_gemma":0.0004930649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01063537,"about_ca_topic_score_gemma":0.0111095,"domain_scores_codex":[0.9988517,0.0002112259,0.0001270998,0.0001849002,0.0004881228,0.0001370716],"domain_scores_gemma":[0.9997333,0.0000542903,0.00004212461,0.00005784196,0.00008013019,0.000032486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001782179,0.0000990788,0.0008207426,0.0001415192,0.0000304701,0.000194371,0.00009576652,0.0001668817,0.9948804,0.0001636471,0.0004821967,0.002746563],"study_design_scores_gemma":[0.00004519716,0.0009707561,0.02266568,0.00003015999,0.00007261383,0.0007072136,0.0002406586,0.002079573,0.9428168,0.0001297599,0.03021206,0.00002953053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9182852,0.01923405,0.02691803,0.001170618,0.0006396437,0.000629466,0.01136701,0.0006416485,0.02111437],"genre_scores_gemma":[0.9239405,0.01426077,0.02461645,0.001300282,0.00009391062,0.0004880945,0.01250967,0.0001294673,0.02266095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063537,"threshold_uncertainty_score":0.02114695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05773565025650859,"score_gpt":0.3544312295572471,"score_spread":0.2966955793007385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}