{"id":"W2166280499","doi":"10.1373/clinchem.2014.225946","title":"Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): Lessons Learned from Patients with Hypercholesterolemia","year":2014,"lang":"en","type":"review","venue":"Clinical Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"PCSK9; Kexin; Proprotein convertase; Subtilisin; Familial hypercholesterolemia; Medicine; Internal medicine; Endocrinology; Cholesterol; LDL receptor; Chemistry; Biochemistry; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001112435,0.0007568178,0.004391058,0.00003529172,0.00009173111,0.00005301044,0.0004325479,0.001570381,0.0003536011],"category_scores_gemma":[0.00122268,0.0005103142,0.001411355,0.0002273057,0.0003227768,0.00004495325,0.0001803439,0.002444292,0.0004230312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878293,"about_ca_system_score_gemma":0.001472671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007145447,"about_ca_topic_score_gemma":0.000004287705,"domain_scores_codex":[0.9951513,0.000365155,0.00161919,0.001429811,0.0008655644,0.0005689131],"domain_scores_gemma":[0.9953434,0.0003329937,0.00068132,0.002464653,0.0003595285,0.0008180654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002669242,0.0004833679,0.001649742,0.02105873,0.0008328273,0.00007402524,0.000005549266,3.772121e-8,0.000001445429,0.000001065439,0.0007066575,0.9749196],"study_design_scores_gemma":[0.003354223,0.0003581429,0.000402843,0.01655887,0.00298173,0.00002460087,0.000005167329,0.000001646158,0.00005465912,0.0000134022,0.9756851,0.0005596274],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02760649,0.9682616,0.0000171232,0.0002792406,0.0003085154,0.002207395,0.0002599234,0.000159836,0.0008998978],"genre_scores_gemma":[0.001573897,0.9891862,0.000360193,0.0004217733,0.002213326,0.0001776917,0.004078298,0.0002266121,0.001762042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9749784,"threshold_uncertainty_score":0.9998571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1318128230743596,"score_gpt":0.4097449191305346,"score_spread":0.277932096056175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}