{"id":"W2166280499","doi":"10.1373/clinchem.2014.225946","title":"Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): Lessons Learned from Patients with Hypercholesterolemia","year":2014,"lang":"en","type":"review","venue":"Clinical Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"PCSK9; Kexin; Proprotein convertase; Subtilisin; Familial hypercholesterolemia; Medicine; Internal medicine; Endocrinology; Cholesterol; LDL receptor; Chemistry; Biochemistry; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006191225,0.0006762065,0.0007947659,0.0005343452,0.0003389647,0.0007799664,0.0005188942,0.001594477,0.0012734],"category_scores_gemma":[0.002344481,0.0002039899,0.000333777,0.0005726107,0.0007389984,0.00118357,0.0004495356,0.002084891,0.0006207772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432529,"about_ca_system_score_gemma":0.000526161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002191523,"about_ca_topic_score_gemma":0.002097288,"domain_scores_codex":[0.9997448,0.00005513642,0.00003663572,0.00007137225,0.000054588,0.00003750784],"domain_scores_gemma":[0.9994517,0.0001920575,0.00006223521,0.00004098784,0.0001337883,0.0001192088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001458285,0.0003888608,0.236046,0.001648416,0.0004421883,0.02576894,0.002598662,0.0004782133,0.005955213,0.003125592,0.04287732,0.6792123],"study_design_scores_gemma":[0.0004876249,0.002107999,0.5530196,0.005769798,0.0009549058,0.1573553,0.007237402,0.001504816,0.004469917,0.02598917,0.240795,0.0003084489],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4291473,0.4424399,0.005831899,0.0989657,0.003713987,0.00009263068,0.001088349,0.0002322434,0.01848803],"genre_scores_gemma":[0.7463635,0.2229336,0.002712277,0.01500238,0.008042917,0.00005149035,0.0007744533,0.00006186838,0.004057663],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002191523,"threshold_uncertainty_score":0.004357576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1318128230743596,"score_gpt":0.4097449191305346,"score_spread":0.277932096056175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}