{"id":"W2166321074","doi":"10.1084/jem.20132038","title":"EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization","year":2014,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; McGill University","keywords":"Cell biology; Biology; Src family kinase; Signal transducing adaptor protein; Degranulation; FYN; Signal transduction; Tyrosine kinase; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007409658,0.0003597337,0.0001560036,0.0001579342,0.0001353724,0.000273629,0.0001420946,0.0002425823,0.0008017416],"category_scores_gemma":[0.00006588443,0.0001076477,0.0001335954,0.0001202387,0.0002763599,0.0002781251,0.000292742,0.0004091449,0.0002321813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347322,"about_ca_system_score_gemma":0.0001685258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001271239,"about_ca_topic_score_gemma":0.0002007221,"domain_scores_codex":[0.9999149,0.00001292045,0.00000518354,0.00002218337,0.00002094796,0.00002394491],"domain_scores_gemma":[0.9999592,0.00000469643,0.00001177707,0.00000402877,0.000004474561,0.00001571912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213492,0.00001151314,0.0001200507,0.000021275,0.000001678215,0.00007071283,0.000006906499,0.00004781154,0.9982673,0.0002469128,0.00003765587,0.001046773],"study_design_scores_gemma":[0.00005044396,0.0002732931,0.009542212,0.000006527755,0.00001342383,0.0006573072,0.00005169312,0.002437287,0.9819592,0.0003872273,0.004613793,0.000007631254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877349,0.002538584,0.005769521,0.0001132484,0.00004787582,0.00002236213,0.0001928027,0.0001555204,0.003425189],"genre_scores_gemma":[0.9948621,0.0008844975,0.001581104,0.0000436815,0.00001229843,0.00002158894,0.0002029704,0.00001302426,0.002378721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008017416,"threshold_uncertainty_score":0.00268209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340700058626079,"score_gpt":0.2624429144061334,"score_spread":0.2490359138198726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}