{"id":"W2166324138","doi":"10.1093/nar/gkv182","title":"Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment","year":2015,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; York University; Emory University","keywords":"CIITA; Biology; Gene; Genetics; Enhancer; Chromatin immunoprecipitation; Histone; Major histocompatibility complex; Promoter; Cell biology; Computational biology; Transcription factor; MHC class II; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002104,0.0002517831,0.000361369,0.0004673042,0.0001875691,0.0003654074,0.000222364,0.0002682275,0.001470144],"category_scores_gemma":[0.000345924,0.0002120875,0.0002861406,0.0004365643,0.0001705308,0.0001815868,0.0002278134,0.0004965821,0.0005250321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002481366,"about_ca_system_score_gemma":0.0002223928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001880148,"about_ca_topic_score_gemma":0.00473879,"domain_scores_codex":[0.9998674,0.00001107001,0.000004982396,0.00006406722,0.00002566009,0.00002678532],"domain_scores_gemma":[0.999804,0.00006905468,0.00004149036,0.00002017373,0.00002586263,0.00003944288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560132,0.00002138988,0.01611437,0.0000876073,0.00003438544,0.00004283375,0.00003654298,0.001130843,0.9777433,0.0001379983,0.0001710092,0.00422384],"study_design_scores_gemma":[0.00002670472,0.000229771,0.4432347,0.00002273344,0.0001842986,0.0005599989,0.0001931818,0.03572419,0.5147607,0.0005784495,0.004425997,0.00005935179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895222,0.0005266814,0.006406754,0.00002651268,0.000006159531,0.00001070681,0.002239067,0.0001712211,0.001090827],"genre_scores_gemma":[0.9908739,0.0002013763,0.004548325,0.00004392977,0.000003176046,0.00001731936,0.003607561,0.00006421419,0.0006400561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880148,"threshold_uncertainty_score":0.004918158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2570459553867314,"score_gpt":0.3619044636200822,"score_spread":0.1048585082333507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}