{"id":"W2166328390","doi":"10.1098/rstb.2012.0106","title":"Modular evolution of phosphorylation-based signalling systems","year":2012,"lang":"en","type":"review","venue":"Philosophical Transactions of the Royal Society B Biological Sciences","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genome Canada","keywords":"Phosphorylation; Signalling; Modular design; Biology; Cell biology; Computational biology; Signalling pathways; Signal transduction; Computer science; Evolutionary biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008083484,0.0003151603,0.0007511456,0.00002655083,0.0003227869,0.00001649391,0.0009325118,0.0006288282,0.00003139849],"category_scores_gemma":[0.00009140779,0.0001780073,0.001400437,0.0004896754,0.001480885,0.000006247593,0.00006403406,0.0002979471,0.000002555589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007224552,"about_ca_system_score_gemma":0.0002705469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008349611,"about_ca_topic_score_gemma":5.459802e-7,"domain_scores_codex":[0.997839,0.0003134696,0.0006624028,0.0004761187,0.0003868929,0.0003221349],"domain_scores_gemma":[0.998728,0.0001652486,0.0005402594,0.0003676056,0.0001069217,0.00009197508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003929871,0.006429412,0.002222331,0.04554575,0.004777605,0.000001775001,0.0001094056,0.3469417,0.01563401,0.1046844,0.0002847143,0.4729759],"study_design_scores_gemma":[0.004148045,0.01162924,0.001018753,0.03472043,0.01367381,0.0000709521,0.0003847436,0.06458846,0.1009826,0.03764012,0.7208406,0.01030217],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0001195808,0.95702,0.04151987,0.00009342063,0.0002546822,0.0006363427,0.0002890821,0.00001480452,0.00005216111],"genre_scores_gemma":[0.5908544,0.4076801,0.001052385,0.00001527026,0.0002263567,0.00009599016,0.0000486975,0.00001404872,0.0000127454],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.7205559,"threshold_uncertainty_score":0.7258928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07268471689332384,"score_gpt":0.2979430425075543,"score_spread":0.2252583256142304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}