{"id":"W2166338434","doi":"10.1113/jphysiol.2011.210237","title":"Robust L‐type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heart","year":2011,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Stony Brook University; American Heart Association","keywords":"Knockout mouse; Cav1.2; Ventricle; Gene knockout; Internal medicine; Endocrinology; Contractility; Calcium channel; Gene expression; Voltage-dependent calcium channel; Wild type; Biology; Allele; Cre recombinase; Cardiac function curve; Transgene; Gene; Calcium; Genetically modified mouse; Heart failure; Mutant; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003651469,0.0006391134,0.0005726732,0.0005662104,0.0001774941,0.0005413319,0.0003842545,0.000719714,0.001639925],"category_scores_gemma":[0.0002787016,0.0004537548,0.0004465675,0.0001657926,0.000505433,0.0003696966,0.0003365319,0.00129536,0.0006769094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500122,"about_ca_system_score_gemma":0.0001931616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639178,"about_ca_topic_score_gemma":0.0003923115,"domain_scores_codex":[0.999577,0.00003503455,0.00005921319,0.0001429289,0.0001006491,0.00008513204],"domain_scores_gemma":[0.9994061,0.00006110586,0.0002535554,0.00006350878,0.00004475941,0.000171013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004759464,0.000008901483,0.0001023888,0.00001276811,0.000002990155,0.0000501281,0.00001056901,0.00001134328,0.9995289,0.00002200226,0.00001179022,0.0001906809],"study_design_scores_gemma":[0.00005316674,0.0006241123,0.0161961,0.00001662719,0.00004752728,0.0009687861,0.00005254342,0.0006009595,0.9803626,0.00007318142,0.0009871299,0.00001720087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924597,0.0008777774,0.00490832,0.00009929508,0.00004726817,0.0000300063,0.000623104,0.0002780864,0.000676406],"genre_scores_gemma":[0.9865617,0.0008823031,0.005067216,0.0001832586,0.00004969057,0.0001625937,0.001319572,0.0002163427,0.005557337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639925,"threshold_uncertainty_score":0.005486131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04005622935349504,"score_gpt":0.2808467271050391,"score_spread":0.240790497751544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}