{"id":"W2166355332","doi":"10.1172/jci45636","title":"Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Pelvic floor disorders treatments","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; Welch Foundation; National Institute on Aging; National Institutes of Health; American Heart Association","keywords":"Fibulin; Extracellular matrix; Matricellular protein; Fibronectin; Matrix metalloproteinase; Downregulation and upregulation; Integrin; Cell biology; Elastic fiber; Proteases; Biology; Medicine; Pathology; Internal medicine; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001371381,0.0001161683,0.0005534466,0.0001859211,0.00002108201,0.000007374785,0.00007942666,0.0001399317,0.00003357022],"category_scores_gemma":[0.002590007,0.0000858727,0.00009586833,0.0002058982,0.0001578653,0.0001778271,0.00002744062,0.0002991153,0.000006376035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003360159,"about_ca_system_score_gemma":0.0002449801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002897532,"about_ca_topic_score_gemma":0.00001715417,"domain_scores_codex":[0.9977302,0.000193006,0.00144877,0.00015874,0.000328404,0.0001408636],"domain_scores_gemma":[0.9982005,0.0001402355,0.0008769972,0.00013098,0.0003247583,0.0003265181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00157832,0.001071268,0.9636592,0.0001760849,0.00008373131,0.000127391,0.001150807,0.000001904169,0.02565576,0.0001322127,0.0002041164,0.006159173],"study_design_scores_gemma":[0.00835675,0.004621924,0.9573884,0.001752818,0.0002731785,0.00008528863,0.000192341,0.0001217753,0.02415342,0.002717719,0.0002181689,0.0001182375],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963238,0.001540127,0.0001051658,0.001101903,0.00009562047,0.0007775518,0.000002785773,0.00000794311,0.00004508043],"genre_scores_gemma":[0.9859976,0.00007931045,0.0135638,0.00009873808,0.00008768663,0.000009616403,0.000004746304,0.0000135535,0.000144935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01345863,"threshold_uncertainty_score":0.3501787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07295887167957309,"score_gpt":0.3860493098195082,"score_spread":0.3130904381399351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}