{"id":"W2166371133","doi":"10.1093/aje/kws031","title":"The Association Between Complement Component 2/Complement Factor B Polymorphisms and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis","year":2012,"lang":"en","type":"review","venue":"American Journal of Epidemiology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Tufts University School of Medicine; National Institutes of Health; Queen's University; Leibniz-Gemeinschaft; Tufts Medical Center; Mahidol University; Hunter Medical Research Institute; University of Oregon","keywords":"Minor allele frequency; Allele; Odds ratio; Single-nucleotide polymorphism; Genotype; Meta-analysis; Allele frequency; Relative risk; Confidence interval; Macular degeneration; Genetics; Population; Medicine; Biology; Internal medicine; Gene; Ophthalmology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0034457,0.0004613018,0.009292835,0.0002035219,0.0001822771,0.00001641229,0.000155132,0.00009826549,0.0003160121],"category_scores_gemma":[0.0004346314,0.0002297003,0.002587803,0.0003710586,0.0002587638,0.00004007306,0.00009197255,0.0004237656,0.000006783133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00033994,"about_ca_system_score_gemma":0.0001017065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001369335,"about_ca_topic_score_gemma":0.00001092366,"domain_scores_codex":[0.9926724,0.003578867,0.002639919,0.0003232469,0.0003306403,0.0004549181],"domain_scores_gemma":[0.9906967,0.002895494,0.005399989,0.0003497035,0.0001815145,0.0004765459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00002428931,0.0001284345,0.02845222,0.002351388,0.6394969,0.00006209046,0.00002974962,7.644087e-7,2.003269e-7,0.0004565045,0.000926658,0.3280708],"study_design_scores_gemma":[0.0001943645,0.0004043284,0.01157392,0.000253414,0.5873427,0.000119771,0.000006145064,9.998778e-7,3.36188e-8,0.00003683352,0.399946,0.000121557],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001963437,0.9930214,0.0001565534,0.005445165,0.00004816246,0.000851105,0.0002573934,0.00000527046,0.00001859676],"genre_scores_gemma":[0.002086971,0.9950655,0.001029647,0.001055154,0.0001261374,0.00005134627,0.0004591878,0.0000253122,0.000100804],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3990193,"threshold_uncertainty_score":0.9366908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2211342227097987,"score_gpt":0.4356572791550274,"score_spread":0.2145230564452287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}