{"id":"W2166376619","doi":"10.4049/jimmunol.171.9.4773","title":"Inhibition of Neutrophil Leukotriene B4 Production by a Novel Synthetic <i>N</i> -3 Polyunsaturated Fatty Acid Analogue, β-Oxa 21:3 <i>n</i> -3","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"","keywords":"Arachidonic acid; Zileuton; Leukotriene B4; Chemistry; Polyunsaturated fatty acid; Ionophore; Biochemistry; Nordihydroguaiaretic acid; Arachidonate 5-lipoxygenase; Docosahexaenoic acid; Calcium; Leukotriene; Lipoxygenase; Fatty acid; Stereochemistry; Biology; Inflammation; Enzyme; Organic chemistry; Immunology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262846,0.0002061694,0.0005677068,0.00021797,0.0001073844,0.000006293771,0.0001273669,0.0001863705,0.00004430161],"category_scores_gemma":[0.0005526152,0.0001317625,0.0001555817,0.0004249426,0.0003467471,0.0001413862,0.00002196008,0.0006376654,0.00001144061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000105123,"about_ca_system_score_gemma":0.0002317824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001867534,"about_ca_topic_score_gemma":0.000002624457,"domain_scores_codex":[0.9981257,0.000381235,0.0007483356,0.0001409557,0.0002959413,0.0003078785],"domain_scores_gemma":[0.9981622,0.0001231034,0.0008271145,0.0003569751,0.0004505969,0.00007997126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001461601,0.000290845,0.0002359501,0.00004774802,0.000206294,0.00002303639,0.0003318112,0.00002282334,0.9951572,0.0001126469,0.001327203,0.0007827946],"study_design_scores_gemma":[0.002474997,0.001400781,0.002403978,0.0002066806,0.0003277392,0.00427863,0.0002647299,0.000009329413,0.9863989,0.00007555375,0.00204058,0.0001181043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912828,0.005208869,0.0006972184,0.001222589,0.001059906,0.0002890044,0.000007126455,0.00001702471,0.0002155196],"genre_scores_gemma":[0.9983468,0.0009040089,0.0001981843,0.0002671221,0.0001761228,0.000003521244,0.000008519466,0.00002689114,0.00006884571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008758349,"threshold_uncertainty_score":0.537312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008780333864193926,"score_gpt":0.2193491215917686,"score_spread":0.2105687877275746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}