{"id":"W2166437657","doi":"10.1039/c4ob02128b","title":"Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives","year":2014,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Innovative Microfluidic and Catalytic Techniques Innovation","field":"Engineering","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Future Earth","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Chemistry; Cascade; Combinatorial chemistry; Flow chemistry; Stereochemistry; Organic chemistry; Catalysis; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377763,0.0001689616,0.0001895547,0.00002914558,0.00006572415,0.00001468314,0.0002570495,0.0001223451,0.0001005545],"category_scores_gemma":[0.0003057149,0.0001367099,0.00006365267,0.0004627446,0.0001016386,0.00003184772,0.0000362966,0.0001140258,0.00000367095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005824621,"about_ca_system_score_gemma":0.00002603745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001239764,"about_ca_topic_score_gemma":4.573419e-8,"domain_scores_codex":[0.999234,0.000009563159,0.0002909426,0.000153093,0.000124094,0.0001882901],"domain_scores_gemma":[0.99931,0.00009192193,0.00007958902,0.0003563433,0.0001426331,0.00001947826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005468591,0.00001327592,0.0000032766,0.0004531851,0.00007482618,4.072397e-7,0.00006080747,0.000001557306,0.9940674,0.00007486794,0.001187885,0.004057003],"study_design_scores_gemma":[0.0001767018,0.00001054259,0.00002555792,0.00006518659,0.00003710436,0.00001256012,0.00005248785,0.007173017,0.9899184,0.0001993718,0.002171082,0.0001579644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0131071,0.0002210658,0.9851671,0.00009827613,0.00003637497,0.0003393579,0.00001898555,0.0002029378,0.0008087979],"genre_scores_gemma":[0.9942499,0.000009447567,0.005331056,0.00003663998,0.00006115833,0.0001648362,0.00003291677,0.00005035194,0.00006363617],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9811429,"threshold_uncertainty_score":0.5574869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005706581697815244,"score_gpt":0.2032593779610954,"score_spread":0.1975527962632801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}