{"id":"W2166481231","doi":"10.1517/14712598.5.6.809","title":"Refining an Alzheimer’s vaccine to avoid an inflammatory response","year":2005,"lang":"en","type":"review","venue":"Expert Opinion on Biological Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Immune system; Meningoencephalitis; Immunotherapy; Immunology; Disease; Medicine; Epitope; Peptide vaccine; Alzheimer's disease; Clinical trial; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001086387,0.001052815,0.001422531,0.001259541,0.0002438737,0.000956226,0.0009733203,0.002086442,0.003564764],"category_scores_gemma":[0.0005714562,0.0002459764,0.0005032466,0.0008775573,0.0005445881,0.001734066,0.000461083,0.001979582,0.003539033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000750869,"about_ca_system_score_gemma":0.0009008569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099285,"about_ca_topic_score_gemma":0.001845847,"domain_scores_codex":[0.9997219,0.00006967358,0.00002571575,0.00003485319,0.0001163911,0.00003130889],"domain_scores_gemma":[0.9998361,0.00004960249,0.00002768649,0.000009094459,0.00005999956,0.00001763059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001465151,0.0001972616,0.0001515317,0.01145322,0.0001071182,0.000418257,0.0000878412,0.0007275201,0.01837922,0.009747033,0.03662121,0.9219633],"study_design_scores_gemma":[0.00009315347,0.0002044493,0.0003624046,0.001757424,0.00007338994,0.0009562082,0.00005228482,0.0001732419,0.002741707,0.003703959,0.9898658,0.00001593869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007261974,0.990985,0.001424695,0.00188572,0.0009087863,0.00003806291,0.00002576096,0.00002961062,0.003976203],"genre_scores_gemma":[0.003245945,0.9874753,0.002646978,0.001995467,0.0004140068,0.00004943743,0.0000661445,0.000005222363,0.004101444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003564764,"threshold_uncertainty_score":0.01192534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3265075297323333,"score_gpt":0.4954910107815169,"score_spread":0.1689834810491836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}