{"id":"W2166483989","doi":"10.1038/mtna.2013.65","title":"Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gene knockdown; Small interfering RNA; RNA interference; In vivo; AMPA receptor; Cell biology; Gene expression; Gene delivery; Gene silencing; Biology; NMDA receptor; Chemistry; Receptor; RNA; Neuroscience; Gene; Genetic enhancement; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001896359,0.0001771681,0.0001499008,0.00005609065,0.00004828645,0.00003504961,0.0005607922,0.0001026096,0.0001074865],"category_scores_gemma":[0.00003849332,0.0001333419,0.0001087795,0.0001683344,0.00007081479,0.00001215518,0.0001216136,0.0000983885,0.00006983615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007769824,"about_ca_system_score_gemma":0.00003413158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005823177,"about_ca_topic_score_gemma":0.000004924628,"domain_scores_codex":[0.9986906,0.0001778655,0.0002637169,0.0003511938,0.0002253899,0.0002912086],"domain_scores_gemma":[0.9991916,0.00002015621,0.0000645733,0.0005604025,0.00009028542,0.00007294617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001083201,0.0001098646,0.001213848,0.000003622125,0.00001482508,0.000006284624,0.0003195424,0.0001714942,0.9891723,0.000009461307,0.001797109,0.007073277],"study_design_scores_gemma":[0.0004499366,0.0007114186,0.009901418,0.00001782932,0.000002859978,0.000007728168,0.0001696454,0.00006510764,0.9853285,0.00006529222,0.003118377,0.0001619123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970388,0.0005744762,0.0008368674,0.0009140358,0.000078552,0.00036427,0.000005849692,0.000008140538,0.0001790207],"genre_scores_gemma":[0.9930049,0.0001578963,0.0006571554,0.00590951,0.00007094362,0.00007181499,0.00001471772,0.00002408887,0.00008897777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008687571,"threshold_uncertainty_score":0.5437526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009848932131436563,"score_gpt":0.231380683702631,"score_spread":0.2215317515711945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}