{"id":"W2166483989","doi":"10.1038/mtna.2013.65","title":"Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gene knockdown; Small interfering RNA; RNA interference; In vivo; AMPA receptor; Cell biology; Gene expression; Gene delivery; Gene silencing; Biology; NMDA receptor; Chemistry; Receptor; RNA; Neuroscience; Gene; Genetic enhancement; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306415,0.0004551705,0.0003797214,0.0002706615,0.0001952881,0.0003105545,0.0002434468,0.0004622403,0.0005795581],"category_scores_gemma":[0.0001233369,0.0001429175,0.0003147931,0.0001247569,0.0002852869,0.0002982998,0.0002466302,0.0005286845,0.0004714488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004142956,"about_ca_system_score_gemma":0.0003618418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005552788,"about_ca_topic_score_gemma":0.001098798,"domain_scores_codex":[0.9998896,0.00001609818,0.00001091712,0.0000278165,0.0000400812,0.00001543695],"domain_scores_gemma":[0.9999508,0.0000104043,0.00001332331,0.000005693932,0.00001242371,0.000007383443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001149674,0.00001006134,0.00001902058,0.00003558371,0.000004246052,0.00003533098,0.00001236354,0.00007020115,0.9973859,0.0001915805,0.00004640097,0.0021778],"study_design_scores_gemma":[0.000009623726,0.0001332694,0.000166999,0.000005026827,0.00001240663,0.0001626006,0.000006691977,0.0007954195,0.9956571,0.00007567136,0.002971407,0.000003738995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8002642,0.01271025,0.1740511,0.00126109,0.0004476504,0.0004160155,0.0003606507,0.0008488376,0.009640245],"genre_scores_gemma":[0.8910584,0.00952116,0.08905643,0.0003655457,0.0000689796,0.0003348677,0.000387763,0.0001536432,0.00905324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005795581,"threshold_uncertainty_score":0.003005922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009848932131436563,"score_gpt":0.231380683702631,"score_spread":0.2215317515711945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}