{"id":"W2166520793","doi":"10.1208/aapsj070489","title":"Role of animal models in the study of drug-induced hypersensitivity reactions","year":2005,"lang":"en","type":"review","venue":"The AAPS Journal","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Drug; Nevirapine; Pharmacology; Mechanism (biology); Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.002016752,0.0003382194,0.001581631,0.0004587915,0.0001810746,0.00002054128,0.0003979983,0.0001580562,0.000007831434],"category_scores_gemma":[0.0001570872,0.0001765038,0.0006232099,0.000725071,0.0000852855,0.0001825877,0.00007517236,0.00240832,0.00001659787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642683,"about_ca_system_score_gemma":0.0006222893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003158084,"about_ca_topic_score_gemma":0.0001522339,"domain_scores_codex":[0.996529,0.001047344,0.001154654,0.0002256894,0.0007364331,0.0003068139],"domain_scores_gemma":[0.99718,0.0005817906,0.001117698,0.0008122044,0.0002074192,0.0001008886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002788886,0.002296988,0.000004398643,0.0004788755,0.0005934789,0.00008494985,0.004161014,0.00006002073,0.0008400482,0.0001671521,0.00003688865,0.9912483],"study_design_scores_gemma":[0.003636725,0.0007617506,0.002295709,0.01555968,0.01284933,0.02733899,0.07523998,0.000347803,0.00004894328,0.0004179935,0.8607825,0.000720621],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1177686,0.8436529,0.000003994625,0.0005462322,0.0003296558,0.002939371,0.0000336156,0.00002906646,0.03469661],"genre_scores_gemma":[0.4256179,0.5737516,0.00002858782,0.00001711552,0.0004432868,0.00001881161,0.000003318677,0.00003759402,0.00008168291],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905277,"threshold_uncertainty_score":0.9998932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1165813435292186,"score_gpt":0.3768291677402214,"score_spread":0.2602478242110028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}