{"id":"W2166527397","doi":"10.1128/jvi.80.3.1487-1496.2006","title":"Canine Adenovirus Vectors for Lung-Directed Gene Transfer: Efficacy, Immune Response, and Duration of Transgene Expression Using Helper-Dependent Vectors","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Association Vaincre la Mucoviscidose; Institut National de la Santé et de la Recherche Médicale; Association pour la Recherche sur le Cancer","keywords":"Biology; Transgene; Adenoviridae; Immune system; Transduction (biophysics); Respiratory tract; In vivo; Genetic enhancement; Ex vivo; Immunology; Viral vector; Virology; Respiratory system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008939838,0.0004735202,0.0003946123,0.00038175,0.0001414452,0.0006198966,0.0003326407,0.0004667597,0.0008041043],"category_scores_gemma":[0.0004829489,0.0002241751,0.0002368476,0.000270183,0.0003298356,0.0005537287,0.0002207126,0.0007926475,0.0003755295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006054972,"about_ca_system_score_gemma":0.0003318963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005440873,"about_ca_topic_score_gemma":0.0007761074,"domain_scores_codex":[0.9994113,0.0001314478,0.00008096095,0.000103223,0.0001746971,0.0000983397],"domain_scores_gemma":[0.9995944,0.0001322306,0.0001067522,0.00005388602,0.00005961261,0.00005312279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111969,0.0000326467,0.0001593624,0.00007735064,0.000004494947,0.00001681175,0.00001472226,0.00005582207,0.9964601,0.0001792969,0.00005917628,0.002828967],"study_design_scores_gemma":[0.00003192275,0.0006356933,0.001512873,0.00001341324,0.00003692215,0.0003783706,0.00001936106,0.001017487,0.990577,0.000071062,0.005694435,0.00001147885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8940545,0.01630499,0.08437358,0.0003994195,0.0002279332,0.0004532878,0.0008223801,0.0006488904,0.002715061],"genre_scores_gemma":[0.9645827,0.004569466,0.02572579,0.00007620745,0.00004919009,0.0001783374,0.001193056,0.0001003056,0.003524925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008939838,"threshold_uncertainty_score":0.0047279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582257718621184,"score_gpt":0.2949228730211518,"score_spread":0.2791002958349399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}