{"id":"W2166535645","doi":"10.2174/1573406411666150212120628","title":"New Testosterone Derivatives as Semi-Synthetic Anticancer Agents Against Prostate Cancer: Synthesis and Preliminary Biological Evaluation","year":2015,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Cyproterone acetate; Prostate cancer; Antiandrogen; Testosterone (patch); Medicine; Abiraterone acetate; LNCaP; Bicalutamide; Androgen; Hormone; Pharmacology; Cancer; Internal medicine; Oncology; Androgen deprivation therapy; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135034,0.0002792439,0.0002197375,0.0001698716,0.00009941962,0.0001407924,0.0001698316,0.0001537584,0.001706523],"category_scores_gemma":[0.00009120419,0.00008135608,0.0001989965,0.0001895422,0.0001057536,0.0001838848,0.0001036804,0.0002901691,0.0004614594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001083605,"about_ca_system_score_gemma":0.0001941632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002726034,"about_ca_topic_score_gemma":0.0005633985,"domain_scores_codex":[0.9999511,0.000009580674,0.000004699716,0.000006621154,0.00001840522,0.000009674573],"domain_scores_gemma":[0.999966,0.000004236413,0.000007210177,0.000002423149,0.000008104765,0.00001209972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003615851,0.0002551012,0.0002071335,0.001562397,0.00003003281,0.0003452948,0.0001166713,0.00156586,0.9690331,0.001338809,0.0005957648,0.02458832],"study_design_scores_gemma":[0.0001234512,0.007107451,0.001988963,0.00006938745,0.00007150687,0.000649888,0.00006823109,0.001129353,0.9517504,0.0002245614,0.03678346,0.00003338263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8681489,0.0915457,0.02203488,0.0002870231,0.000342291,0.0005239418,0.002017133,0.0002116757,0.0148885],"genre_scores_gemma":[0.9425705,0.03725006,0.01208992,0.00014121,0.00009213224,0.0001237959,0.0009663044,0.00002180556,0.006744227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706523,"threshold_uncertainty_score":0.005708873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08506915519158377,"score_gpt":0.3664941828855822,"score_spread":0.2814250276939985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}