{"id":"W2166555377","doi":"10.1523/jneurosci.0913-04.2004","title":"Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid  1-42 Toxicity through Heat Shock Protein 70","year":2004,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"National Institutes of Health; Alzheimer Society","keywords":"Neuroprotection; Flutamide; Androgen receptor; Estrogen receptor; Estrogen; Internal medicine; Endocrinology; Androgen; Hsp70; Biology; Testosterone (patch); Chemistry; Heat shock protein; Pharmacology; Hormone; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007098142,0.0001816279,0.0001334321,0.00009614073,0.00009819214,0.0001177791,0.00006907841,0.00008864697,0.001764162],"category_scores_gemma":[0.00008315033,0.00004521407,0.0001505986,0.0000516017,0.0000865494,0.00006335147,0.00009277265,0.0001705916,0.0002815526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009262299,"about_ca_system_score_gemma":0.0002489015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003219,"about_ca_topic_score_gemma":0.001765273,"domain_scores_codex":[0.9999702,0.000004833093,0.000002394924,0.000003654548,0.000007023048,0.00001189471],"domain_scores_gemma":[0.9999768,0.00000277592,0.000004227806,0.000003277643,0.000005034884,0.000008014217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002288527,0.0003702688,0.001224543,0.0002588257,0.00005911477,0.0002766148,0.0001189111,0.0001919385,0.9715765,0.0003639202,0.0005636316,0.02270724],"study_design_scores_gemma":[0.0004009241,0.006790892,0.04853923,0.0000605321,0.0001771121,0.00121734,0.0001955007,0.0006965279,0.9242077,0.0004307026,0.01727104,0.0000124467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990382,0.006767673,0.0003967925,0.00008671792,0.00003658069,0.00001241283,0.0001541339,0.00004410243,0.002119561],"genre_scores_gemma":[0.9914124,0.003873471,0.0002756106,0.0000770972,0.00001916903,0.00001270732,0.0003168189,0.000005655901,0.004007091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764162,"threshold_uncertainty_score":0.005901694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04419615114378803,"score_gpt":0.3109035460944903,"score_spread":0.2667073949507022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}