{"id":"W2166568854","doi":"10.1158/0008-5472.can-05-0047","title":"Targeted Expression of BRAFV600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":417,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute","keywords":"Thyroglobulin; Thyroid; Sodium-iodide symporter; Thyroid carcinoma; Internal medicine; Endocrinology; Thyroid peroxidase; Goiter; Genetically modified mouse; Triiodothyronine; Thyroid cancer; Medicine; Cancer research; Biology; Transgene; Symporter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006812687,0.000201221,0.0005287037,0.0005930128,0.00004341672,0.000009531331,0.0002107681,0.000171281,0.0001804209],"category_scores_gemma":[0.00005352903,0.0001712699,0.0001197072,0.000853861,0.0001572939,0.0001494899,0.00005784603,0.0004634655,0.000006334655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001578156,"about_ca_system_score_gemma":0.00084837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005928226,"about_ca_topic_score_gemma":0.01024485,"domain_scores_codex":[0.9971079,0.0002666386,0.0006469607,0.0005006011,0.0009154923,0.000562446],"domain_scores_gemma":[0.9987499,0.0002848321,0.0001690403,0.0004373303,0.0002031037,0.0001558215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002852803,0.0006149764,0.02215327,0.0003775327,0.00006029482,0.00001331464,0.002987468,0.001513383,0.960721,0.00002316199,0.004037083,0.004645713],"study_design_scores_gemma":[0.007521445,0.0005359023,0.0966438,0.00105462,0.00002676811,9.871205e-7,0.0006333895,0.0001022031,0.8926278,0.00004982956,0.0006738312,0.0001294565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774559,0.01904265,0.000008806969,0.001714127,0.0001283367,0.000942854,0.0001325292,0.00001473157,0.0005601307],"genre_scores_gemma":[0.9774212,0.02164787,0.0001351578,0.00005696288,0.0001440598,0.0002669663,0.00005919573,0.0000348521,0.0002337965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07449052,"threshold_uncertainty_score":0.8961744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05701681975358119,"score_gpt":0.3594721131494025,"score_spread":0.3024552933958213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}