{"id":"W2166600125","doi":"10.1085/jgp.200308842","title":"Conotoxins as Sensors of Local pH and Electrostatic Potential in the Outer Vestibule of the Sodium Channel","year":2003,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; McMaster University; University of Calgary","keywords":"Chemistry; Batrachotoxin; Sodium channel; Titration; Biophysics; Conductance; Titration curve; Histidine; Sodium; Stereochemistry; Amino acid; Biochemistry; Inorganic chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704487,0.0001539957,0.0001616262,0.0001012225,0.00008339529,0.0002160837,0.0001503366,0.0002119454,0.0004050331],"category_scores_gemma":[0.0002261737,0.00007106073,0.00008310236,0.0001514286,0.000208584,0.0002871337,0.0001451234,0.0003724058,0.00009928575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001814797,"about_ca_system_score_gemma":0.00009731202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004124392,"about_ca_topic_score_gemma":0.0004957207,"domain_scores_codex":[0.9998446,0.00003437791,0.000009684628,0.00002592458,0.0000595084,0.00002595694],"domain_scores_gemma":[0.9998949,0.00002810441,0.00003290279,0.000006058999,0.00001354788,0.00002451609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007344364,0.000005620354,0.0004478487,0.000009640133,0.000001604577,0.00002230917,0.000007862249,0.00009171267,0.9989041,0.00003329078,0.000002594087,0.0003999035],"study_design_scores_gemma":[0.0000163574,0.0003357328,0.009990108,0.000004165393,0.000009372726,0.0001298516,0.00004030581,0.002666063,0.9863777,0.00009256929,0.0003324044,0.000005331223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979417,0.0003252691,0.001399901,0.00002053775,0.000003764077,0.00000691206,0.00005571203,0.00001233457,0.0002338038],"genre_scores_gemma":[0.997892,0.0002374091,0.001478914,0.00002154115,0.000003066061,0.000006610495,0.00009531689,0.00000373757,0.000261351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004124392,"threshold_uncertainty_score":0.001354992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006621040993706704,"score_gpt":0.2234022987727494,"score_spread":0.2167812577790427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}